Highly Diastereoselective Synthesis of cis-3,4-Disubstituted γ-Lactams by the Reaction of Ethyl-2,2-Dialkoxycyclopropanecarboxylates with N-Tosyl Aldimines

DOI: 10.1246/cl.1990.905

Source and publish data:

Chemistry Letters p. 905 - 908 (1990)

Update date:2022-08-04

Topics:

Authors:

Saigo, Kazuhiko

Shimada, Shigeru

Hasegawa, Masaki

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Article abstract of DOI:10.1246/cl.1990.905

In the presence of titanium(IV) chloride, ethyl 2,2-dialkoxycyclopropanecarboxylates reacted with imines to give γ-lactams.Especially, when N-tosyl aldimines were employed, cis-3,4-disubstituted γ-lactams were obtained in good yields with high diastereoselectivity.

Full text of DOI:10.1246/cl.1990.905

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