Highly Diastereoselective Synthesis of cis-3,4-Disubstituted γ-Lactams by the Reaction of Ethyl-2,2-Dialkoxycyclopropanecarboxylates with N-Tosyl Aldimines

DOI: 10.1246/cl.1990.905

Source and publish data:

Chemistry Letters p. 905 - 908 (1990)

Update date:2022-08-04

Topics:

Authors:

Saigo, Kazuhiko

Shimada, Shigeru

Hasegawa, Masaki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1990.905

In the presence of titanium(IV) chloride, ethyl 2,2-dialkoxycyclopropanecarboxylates reacted with imines to give γ-lactams.Especially, when N-tosyl aldimines were employed, cis-3,4-disubstituted γ-lactams were obtained in good yields with high diastereoselectivity.

Full text of DOI:10.1246/cl.1990.905

Products guided by the article

Product name:trans-N-p-nitrophenyl 3-ethoxycarbonyl-2,2-dimethyl-4-phenyl-4-butanelactam

Cas No:130232-06-3

R&D Labs maybe for 130232-06-3

Tianjin SPHINX SCIENTIFIC LAB.

Contact:+86-022-66211289

Address:Tianda high-tech Park. No.80,the 4th Avenue
HEBEI BRANT PHARMACEUTICAL

Contact:+86-0311-84455288-844

Address:Mayu Industrial Park, Jinzhou, Hebei, China.
SHIJIAZHUANG AGERUO-BIOTECH CO.LTD

Contact:+86-130-2866-6699

Address:Huaian east Road 158
Chengdu NoVi Biotechnology Co., Ltd.(expird)

Contact:13551243286/028-81458053

Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
CHENGDU CHENLV HERB CO.,LTD

Contact:+86-28-88523492

Address:714rooms of Time Square, Pujiang County

Relevant to this article

The use of novel biodegradable, optically active and nanostructured poly(amide-ester-imide) as a polymer matrix for preparation of modified ZnO based bionanocomposites

Doi:10.1016/j.materresbull.2012.02.015
(2012)
Copper-catalyzed direct amination of electron-deficient arenes with hydroxylamines

Doi:10.1021/ol200855t
(2011)
Substrate-controlled regioselective cobalt(I)-catalysed 1,4-hydrovinylation reactions

Doi:10.1055/s-0030-1258408
(2011)
Synthesis of C₃ and C_s symmetric cyclic triglycerols

Doi:10.3987/COM-10-S(E)75
(2011)
ALLYLIC 1,3-REARRANGEMENT OF 1-ALKOXYALLYLPHOSPHONIUM SALTS. REGIOCHEMISTRY OF REACTION OF 1-ALKOXY-2-ALKENYLENEPHOSPHORANES WITH ALDEHYDES

Doi:10.1016/0040-4039(90)80179-P
(1990)
Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities

Doi:10.1007/s12272-011-0101-8
(2011)

Article Doi