Utilization of chloroacetone in the synthesis of 3-methylindoles

Article abstract of DOI:10.1080/00397919208055410

Synthesis of 3-methylindoles 2 and 5 are described starting from chloroacetone and the corresponding monoalkylated anilines utilizing a modified alkylation-cyclization sequence. Compound 5 was converted in high yield into a very useful oxindole 7 in two steps.

Full text of DOI:10.1080/00397919208055410

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Utilization of Chloroagetone
in the Synthesis of 3-
Methylindoles
Russell Underwood a , Kapa Prasad a , Oljan Repic a
& Goetz E. Hardtmann a
a Sandoz Research Institute East Hanover, New
Jersey, 07936, USA
Version of record first published: 05 Dec 2006.
To cite this article: Russell Underwood , Kapa Prasad , Oljan Repic & Goetz E.
Hardtmann (1992): Utilization of Chloroagetone in the Synthesis of 3-Methylindoles,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 22:3, 343-349
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