Synthesis and Evaluation of Potent and Selective c-GMP Phosphodiesterase Inhibitors

Article abstract of DOI:10.1016/S0960-894X(98)00681-7

Syntheses and structure-activity relationships (SAR) of cGMP selective phosphodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted with alkyl chains containing six carbon atoms.