Zur Stereochemie der mikrobiellen Reduktion von rac-Acetyl(t-butyl)methylphenylsilan mit Trigonopsis variabilis (DSM 70714) und Corynebacterium dioxydans (ATCC 21766): Aufklaerung der absoluten Konfiguration der Biotransformationsprodukte (SiR,CR)- und (SiS,CR)-t-Butyl(1-hydroxyethyl)...

Article abstract of DOI:10.1016/0022-328X(92)80002-F

The stereochemistry of the microbial reduction of rac-acetyl(t-butyl)methylphenylsilane (rac-1) with cells of Trigonopsis variabilis (DSM 70714) and Corynebacterium dioxydans (ATCC 21766) has been studied.The absolute configuration of the diastereomeric biotransformation products (SiR,CR)- and (SiS,CR)-t-butyl(1-hydroxyethyl)methylphenylsilane ((Si,R,CR)-2 and (SiS,CR)-3) has been determined on the basis of a single-crystal X-ray diffraction study of (SiS,CS,C'R)-t-butylmethyl<1-ethyl>phenylsilane ((SiS,CS,C'R)-5).