Tetrahedron p. 1715 - 1728 (1992)
Update date:2022-08-03
Topics:
Berkowitz, David B.
Schweizer, W. Bernd
Two diastereomeric reductive amination reagents, 1a and 1b, were synthesized. Each reagent was condensed with ethyl pyruvate as a model α-keto acid. Flash vacuum pyrolysis of the pyruvate adducts, 10a and 10b, results in cheleotropic elimination of CO, followed by a new type of retro-aza-ene reaction. A molecule of benzene and a protected alanine derivative, 11, are produced in the retro-ene reaction. This sequence constitutes the first formal more readily than distereomer 10a, indicating that an exo transition state is preferred over an endo transition state for this particular retro-aza-ene reaction.
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(1992)
