Selective oxidation of terminal isopropyl groups to tertiary alcohols by electrochemical methodology

Article abstract of DOI:10.1016/S0040-4039(97)01650-X

Selective oxidation of terminal isopropyl groups to the corresponding tertiary alcohols by an electrochemical method is described. Under the conditions using the TI(TFA)₃-hematoporphyrin-O₂- cathode reduction system, several substrates such as cholesterol (1) and Grundmann's alcohol (3) gave the corresponding tertiary alcohols 2 and 4, respectively, in reasonable yield.