SYNTHESIS OF trans-2-IMINOTHIAZOLIDINE AND RELATED COMPOUNDS - A NEW CLASS OF ANTIDEPRESSANTS

Article abstract of DOI:10.1135/cccc19920415

Antiparasitic and antidepressant activities exhibited by tetramisole (I) and its enantiomers prompted the study of its structural analogs trans-2-iminothiazolidine (VIII/IX) and 2,3,4a,5,6,10b-hexahydronaphtho<1',2':4,5>imidazo<2,1-b>thiazole (XII), 2,3,4a,5-tetrahydro-9bH-indeno<1',2':4,5>imidazo<2,1-b>thiazole (XIII), and 2,3,4a,5-tetrahydro-9bH-indeno<1',2':4,5>imidazo<2,1-b>thiazole (XVI), and a homolog 3,4,6,7-tetrahydro-7-phenyl-2H-imidazo<2,1-b>-1,3-thiazine (XX).While none of these compounds showed any noteworthy antiparasitic activity, the trans-2-iminothiazolidine (VIII) has shown marked antidepressant activity, better than imipramine in the tests used, and provides a new structural lead for antidepressants.