Solvent-free synthesis of 2-(phenylamino)-4-(trifluoromethyl)-1,6- dihydropyrimidine derivatives catalyzed by sulfamic acid

Article abstract of DOI:10.1002/jhet.912

A series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions. This protocol has the advantages of mild condition, high yields and environmentally benign procedure.