Synthesis of 3-1,4-Dihydropyridine-3,5-dicarboxylate Derivaties as Calcium Channel Modulators

DOI: 10.1021/jm00091a008

Source and publish data:

Journal of Medicinal Chemistry p. 2407 - 2414 (1992)

Update date:2022-08-03

Topics:

Authors:

Sunkel, Carlos E.

Casa-Juana, Miguel Fau de

Santos, Luis

Garcia, Antonio G.

Artalejo, Cristina R.

et al. et al.

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Article abstract of DOI:10.1021/jm00091a008

1,4-Dihydropyridine (DHP) derivatives with a 1,2-benzisothiazol-3-one 1,1-dioxide group, linked through an alkylene bridge to the C-3 carboxylate of the DHP ring, with both vasoconstricting and vasorelaxant properties were obtained.In blocking Ca^{2+
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Full text of DOI:10.1021/jm00091a008

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Product name:3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2,6-dimethyl-, (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl (tetrahydro-2-furanyl)methyl ester

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