Targeting the Warburg Effect in cancer; Relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)

DOI: 10.1016/j.bmc.2013.12.041

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1029 - 1039 (2014)

Update date:2022-07-29

Topics: Inhibitors

Authors:

Brooke, Darby G.

Van Dam, Ellen M.

Watts, Colin K.W.

Khoury, Amanda

Dziadek, Marie A.

Brooks, Hilary

Graham, Lisa-Jane K.

Flanagan, Jack U.

Denny, William A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmc.2013.12.041

High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3) Such inhibitors are of interest due to PFKFB3's

Full text of DOI:10.1016/j.bmc.2013.12.041

Products guided by the article

Product name:4,5-dibromo-2-(4-chlorophenyl)pyridazin-3(2H)-one

Cas No:14132-96-8

R&D Labs maybe for 14132-96-8

xuri chemicals co., ltd

Contact:86-516-66656369

Address:The west road of Huaihai, Xuzhou, China
Jintan Jinnuo Chemical Co., Ltd.

Contact:+86-519-80199901

Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Luojiang Chenming Biological Products Co

Contact:+86 15000297032

Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Changzhou Ansciep Chemical Co.,Ltd.

Contact:+86 519 8630 5871

Address:A-710 Boan International, 8 East Guangdian Road,Wujin,Changzhou
AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA

Relevant to this article

Doi:10.1016/S0040-4020(01)82175-X
(1966)
Outer-sphere coordination chemistry: Amido-ammonium ligands as highly selective tetrachloridozinc(II)ate extractants

Doi:10.1021/ic301691d
(2012)
A simple and expedient synthesis of functionalized pyrido[2,3-c] coumarin derivatives using molecular iodine catalyzed three-component reaction

Doi:10.1016/j.tetlet.2012.09.051
(2012)
An Efficient Approach toward 2,3-Dimethylene Pyrroles. Preparation and Reactions of Pyrrolo-3-sulfolenes

Doi:10.1039/c39920000549
(1992)
Synthesis of dialkyl and diaryl benzylphosphonates through a ZnI ₂-mediated reaction

Doi:10.1016/j.tetlet.2012.09.114
(2012)
Structure dependence of long-chain [¹⁸F]fluorothia fatty acids as myocardial fatty acid oxidation probes

Doi:10.1021/jm301345v
(2012)

Article Doi