Bioorganic and medicinal chemistry letters p. 653 - 658 (2002)
Update date:2022-08-04
Topics:
Andres, J Ignacio
Alonso, Jose M
Diaz, Adolfo
Fernandez, Javier
Iturrino, Laura
Martinez, Pedro
Matesanz, Encarna
Freyne, Eddy J
Deroose, Frederik
Boeckx, Gustaaf
Petit, Davy
Diels, Gaston
Megens, Anton
Somers, Marijke
Van Wauwe, Jean
Stoppie, Paul
Cools, Marina
De Clerck, Fred
Peeters, Danielle
de Chaffoy, Didier
This communication describes the synthesis and in vitro PDE4 inhibitory activity of a novel series of imidazol-2-one and 2-cyanoiminoimidazole derivatives. The compounds described were also tested in in vivo models to evaluate their anti-inflammatory activity after topical administration as well as their gastro-intestinal side effects. Several compounds proved to be potent PDE4 inhibitors and some 2-cyanoiminoimidazoles showed less pronounced gastro-intestinal side effects than reference compounds but maintained anti-inflammatory activity after topical administration.
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Doi:10.1055/s-1976-24090
(1976)Doi:10.1016/S0022-328X(00)92149-1
(1976)Doi:10.1021/ja00442a017
(1976)Doi:10.1039/C39760000592
(1976)Doi:10.1002/chem.200600832
(2006)Doi:10.1021/jo01303a030
(1980)