Enzymatic asymmetric synthesis of cis-4-cyclopentene-1,3-dimethanol monoacetate

Article abstract of DOI:10.1016/S0957-4166(00)80286-4

Asymmetric synthesis of cis-4-cyclopentene-1,3-dimethanol monoacetate was performed via enzymatic hydrolysis of the diacetate or enzymatic acetylation of the diol precursor. Esterases and lipases were studied, and Candida cylindracea lipase was shown to afford the (-)-enantiomer with ee>97%.