Preparation of Polyfunctional Allenic Alcohols by the Regioselective Addition of Functionalized Propargylic Chromium(III) Organometallics to Carbonyl Compounds

DOI: 10.1021/jo00041a006

Source and publish data:

Journal of Organic Chemistry p. 4070 - 4074 (1992)

Update date:2022-07-30

Topics:

Authors:

Belyk, Kevin

Rozema, Michael J.

Knochel, Paul

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00041a006

The reaction of propargylic halides 1 (X = Cl, Br) with an aldehyde or ketone (0.67 equiv) in the presence of CrCl2 (2.0 equiv) and LiI (2 equiv, necessary if X = Cl) affords allenic alcohols 3 with excellent regioselectivities (3-6percent of the regioiso

Full text of DOI:10.1021/jo00041a006

Products guided by the article

Product name:2-butyl-1-cyclohexyl-2,3-butadien-1-ol

Cas No:141375-85-1

R&D Labs maybe for 141375-85-1

JiangXi Keyuan Biopharma Co., LTD.

Contact:+86-563-6833666

Address:Guangde Fine Chemical Zone, Anhui Province, China
Jinan Jianfeng Chemical Co., Ltd

Contact:0086-531-88110457

Address:sales01(-a-t-)pharmachemm{dot}c+o+m
QINGDAO DEVELOP chemistry Co.,Limited

Contact:+86-532-85807910

Address:98#Nanjing Road, Qingdao, China 266071
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd

Contact:028-85317716

Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
Chen jie

Contact:027-87677569

Address:Room 2203, yujingmingmen Buidling One, xiongchu Road, wuhan city, hubei province, China

Relevant to this article

Reactivity enhancement of a diphosphene by reversible N-heterocyclic carbene coordination

Doi:10.1039/c8sc00348c
(2018)
Iodine-mediated α-acetoxylation of 2,3-disubstituted indoles

Doi:10.1021/ol302983t
(2012)
Three-component reaction of propargyl amines, sulfonyl azides, and alkynes: One-pot synthesis of tetrasubstituted imidazoles

Doi:10.1021/ol303023y
(2012)
Synthesis of 2,5-Disubstituted Oxazoles from Arylacetylenes and α-Amino Acids through an i ₂ /Cu(NO ₃) ₂ ?3H ₂ O-Assisted Domino Sequence

Doi:10.1055/s-0037-1612087
(2019)
Iridium-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones: Enantioselective total synthesis of (-)-mesembrine

Doi:10.1021/ol302842h
(2012)
(E)-N′-(4-Chlorobenzylidene)-,(E)-N′-(4-bromobenzylidene)- and (E)-N′-[4-(diethylamino)benzylidene]-derivatives of 4- hydroxybenzohydrazide

Doi:10.1107/S0108270112038462
(2012)

Article Doi