Preparation of Polyfunctional Allenic Alcohols by the Regioselective Addition of Functionalized Propargylic Chromium(III) Organometallics to Carbonyl Compounds

DOI: 10.1021/jo00041a006

Source and publish data:

Journal of Organic Chemistry p. 4070 - 4074 (1992)

Update date:2022-07-30

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Authors:

Belyk, Kevin

Rozema, Michael J.

Knochel, Paul

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Article abstract of DOI:10.1021/jo00041a006

The reaction of propargylic halides 1 (X = Cl, Br) with an aldehyde or ketone (0.67 equiv) in the presence of CrCl2 (2.0 equiv) and LiI (2 equiv, necessary if X = Cl) affords allenic alcohols 3 with excellent regioselectivities (3-6percent of the regioiso

Full text of DOI:10.1021/jo00041a006

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