Tetrahedron p. 2069 - 2080 (1992)
Update date:2022-08-04
Topics:
Park, Jeonghan
Pedersen, Steven F.
A general and practical method for the direct hydroxymethylation of aldehydes and ketones via pinacol cross-coupling with paraformaldehyde is described. The reaction is promoted by vanadium(II) ions which are conveniently generated from the reduction of VCl3(THF)3 with zinc dust. Excellent yields of terminal diols are obtained and stereoselective coupling is observed with some chiral aldehydes and ketones.
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