Synthesis and optical resolution of an antiallergic agent KW4099 with thromboxane A2 antigonistic activity

DOI: 10.1248/cpb.40.238

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 238 - 239 (1992)

Update date:2022-07-30

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Authors:

Sugaya Sugaya

Kuge Kuge

Tomioka Tomioka

Tamaki Tamaki

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Article abstract of DOI:10.1248/cpb.40.238

A new antiallergic agent with thromboxane A₂ antagonistic activity, KW4099, was synthesized by a simple method. Its optical resolution was accomplished with the use of (+)- or (-)-2,2'-(1,1'-binaphthyl)phosphoric acid as a resolving agent.

Full text of DOI:10.1248/cpb.40.238

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