Quinazoline antifolate thymidylate synthase inhibitors: Difluoro- substituted benzene ring analogues

DOI: 10.1021/jm00090a024

Source and publish data:

Journal of Medicinal Chemistry p. 2321 - 2327 (1992)

Update date:2022-08-05

Topics:

Authors:

Thornton

Jackman Jackman

Marsham Marsham

O'Connor

Bishop Bishop

Calvert Calvert

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Article abstract of DOI:10.1021/jm00090a024

The synthesis of a series of new C²-methyl-N¹⁰-alkylquinazoline-based thymidylate synthase (TS) inhibitors containing difluorinated p-aminobenzoate rings is described. Derivatives of the N¹⁰-propargyl and N¹⁰- m

Full text of DOI:10.1021/jm00090a024

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