Synthesis of the Aziridinopyrrolidine Substructure of the Antitumor Agents Azinomycin A and B

DOI: 10.1021/jo00048a006

Source and publish data:

Journal of Organic Chemistry p. 5813 - 5815 (1992)

Update date:2022-08-03

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Authors:

Coleman, Robert S.

Carpenter, Andrew J.

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Article abstract of DOI:10.1021/jo00048a006

A stereoselective synthesis of the central aziridino<1,2-a>pyrrolidine substructure (19) of the antitumor agents azinomycin A and B is reported and featured as the key step an intramolecular Michael addition-elimination reaction between the aziridine and

Full text of DOI:10.1021/jo00048a006

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