Palladium-catalyzed stereocontrolled endo cyclization of 3-hydroxypropyl-1,3-cyclohexadiene leading to versatile fused tetrahydropyrans

Article abstract of DOI:10.1016/0040-4039(95)00989-P

A palladium-catalyzed synthesis of stereodefined fused tetrahydropyrans from 2-substituted 1,3-cyclohexadienes is presented. The reaction takes place via an intramolecular 1,4-oxidation of the conjugated diene via a (π-allyl)palladium intermediate. The st