Total synthesis of (+/-)-acetomycin and design of esterase-resistant analogs.

DOI: 10.1248/cpb.47.517

Source and publish data:

Chemical and pharmaceutical bulletin p. 517 - 523 (1999)

Update date:2022-08-03

Topics:

Authors:

Uenishi Uenishi

Kobayashi

Komine Komine

Okadai Okadai

Yonemitsu

Sasaki Sasaki

Yamada Yamada

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Article abstract of DOI:10.1248/cpb.47.517

The synthesis of acetomycin and related analogs was investigated. Acetomycin was synthesized from diethyl allyl(methyl)malonate in 6.5% yield over 18 steps. The total number of steps was improved compared to our previous synthesis; i.e., four steps shorte

Full text of DOI:10.1248/cpb.47.517

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