ω-alkanoic Acid Derivatives: A New Family of Potent LTB4 Antagonists

DOI: 10.1021/jm00101a007

Source and publish data:

Journal of Medicinal Chemistry p. 4306 - 4314 (1992)

Update date:2022-08-04

Topics:

Authors:

Labaudiniere, Richard

Hendel, Wolfram

Terlain, Bernard

Cavy, Francoise

Marquis, Olivier

Dereu, Norbert

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Article abstract of DOI:10.1021/jm00101a007

A series of ω-<(4-phenyl-2-quinolyl)oxy>alkanoic acid derivatives was prepared which inhibited the binding of the leukotriene B₄ to its receptors on guinea pig spleen membranes and on human polymorphonuclear leukocytes.A structure-activity rela

Full text of DOI:10.1021/jm00101a007

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Product name:Hexanoic acid, 2,2-dimethyl-6-[[4-(4-nitrophenyl)-2-quinolinyl]oxy]-, methyl ester

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