Studies on the synthesis of 8-alkyl-8-aryl-2-azabicyclo[3.3.1]nonan-7-ones. A short synthetic route to functionalized 8-alkyl derivatives

Article abstract of DOI:10.1016/S0040-4020(01)92254-9

Two approaches to 8-alkyl-8-aryl-2-azabicyclo[3.3.1]nonan-7-ones are explored. They are based on the cyclization of an α-alkyl α-aryl ketone upon an iminium salt generated from 2-cyanopiperidine 13 and on the arylation of 8-alkyl-2-azabicyclo[3.3.1]nonan-