
Chemical and Pharmaceutical Bulletin p. 593 - 598 (1992)
Update date:2022-08-02
Topics:
Nagai
Nishioka
Koyama
Ando
Miki
Kumadaki
In the course of our study on the ene reaction of trifluoromethyl ketones, a trifluoromethyl group has been observed to behave as a larger substituent than commonly believed in the biomedicinal field. To estimate the steric eflect of a trifluoromethyl gro
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