Reactions of trifluoromethyl ketones. VIII. Investigation of steric effects of a trifluoromethyl group through ene reaction of trifluoromethyl ketones

DOI: 10.1248/cpb.40.593

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 593 - 598 (1992)

Update date:2022-08-02

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Authors:

Nagai Nagai

Nishioka

Koyama Koyama

Ando Ando

Miki Miki

Kumadaki

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Article abstract of DOI:10.1248/cpb.40.593

In the course of our study on the ene reaction of trifluoromethyl ketones, a trifluoromethyl group has been observed to behave as a larger substituent than commonly believed in the biomedicinal field. To estimate the steric eflect of a trifluoromethyl gro

Full text of DOI:10.1248/cpb.40.593

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