Synthesis of tetracyclic aza-/oxa-naphthalen-8-ones and their antimicrobial activity

Article abstract of DOI:10.1007/s00044-012-0425-z

Tetracyclic azanaphthalen-8-ones are synthesized by condensing 3-bromo-4-methyl benzo[h]-chromen-2-one with different primary aromatic amines. 3-Bromo-4-methylbenzo[h]chromen-2-one is synthesized by bromination of 4-methylbenzo[h]chromen-2-one using N-bromosuccinimide. Condensation of 3-bromo-4-methylbenzo[h]chromen-2-one with different secondary cyclic amines gave tetracyclic oxa-naphthalen-9-one. All the synthesized compounds were screened for their antimicrobial activity and they show good results.