S-2-(2,4-dinitrophenyl)ethyl-L-cysteine: A new derivative for solid-phase peptide synthesis

Article abstract of DOI:10.1016/S0040-4039(00)74220-1

A new acid stable protecting group for the sulfhydryl function of cysteine is described. The S-2-(2,4-dinitrophenyl)ethyl-L-cysteine derivative is fully compatible with the Boc/Bzl solid-phase peptide synthesis strategy and can be smoothly and quantitatively removed to give the free thiol or a disulfide bridge.