The tert-butyl sulfoxide directed ortho metalation group. New synthetic methodology for substituted aromatics and pyridines and comparison with other metalation directors

Article abstract of DOI:10.1016/S0040-4039(00)79042-3

Details of the directed ortho metalation of tert-butyl phenyl sulfoxide (1) and 2- and 4-tert-butyl pyridyl sulfoxides (3a,b) are described along with comparisons with established metalation directors (CONR₂, OCONR₂, OMOM, SO₂t-Bu) via inter- and intramolecular competition experiments.