Organic & Biomolecular Chemistry
Paper
also presented the first example of a benzimidazolium-based
compound that can transport anions and cations across lipo-
somes, as well as bacterial membranes, via a channel for-
mation pathway. The ability of 4 to drill transient channels
through the robust wall of bacterial cells should make it attrac-
tive as a paradigm for designing future antibiotic transporters
across resistant bacterial membranes. Characterization of the
membrane-spanning channel’s size and its ability to transport
other molecules need further insight and are currently being
investigated in our laboratory.
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Acknowledgements
We are grateful to the Natural Sciences and Engineering
Research Council of Canada (NSERC), Fonds Québécois de la
Recherche sur la Nature et les Technologies (FQRNT), Centre
in Green Chemistry and Catalysis (CCVC), Canada Foundation
for Innovation (CFI) and Université de Montreal for financial
support. We thank Prof. J.N. Pelletier for access to her bacterial
incubator. We also thank colleagues for a careful reading and
discussion of this manuscript.
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