A CONVENIENT STEREOSELECTIVE SYNTHESIS OF CONJUGATED (2Z)-EN-4-YNOIC AND (2Z,4Z)- AND (2Z,4E)-DIENOIC ACID DERIVATIVES FROM PROPIOLIC ACID DERIVATIVES

Article abstract of DOI:10.1016/S0040-4039(00)92235-4

The palladium-catalysed one-pot sequential reaction of propiolic acid derivatives with lithium halides first, and then with terminal alkynes or alkenes affords conjugated (2Z)-en-4-ynoic and (2Z,4Z)- and (2Z,4E)-dienoic acid derivatives with high stereoselectivity.