Tetrahedron p. 4115 - 4122 (1992)
Update date:2022-08-04
Topics:
Patino, Nadia
Frerot, Eric
Galeotti, Nathalie
Poncet, Joel
Coste, Jacques
et al.
Efficient synthesis of dolastatin 15 (1) was accomplished following a convergent strategy.The pyrrolidinone cycle of 5 was obtained by thermic cyclization of the corresponding Meldrum's adduct 4.The methylation of the enol function was performed under Mit
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