Antiviral and Antitumor Structure-Activity Relationship Studies on Tetracyclic Eudistomines

DOI: 10.1021/jm00095a019

Source and publish data:

Journal of Medicinal Chemistry p. 3223 - 3230 (1992)

Update date:2022-08-04

Topics:

Authors:

Maarseveen, Jan H. Van

Hermkens, Pedro H. H.

Clercq, Erik De

Balzarini, Jan

Scheeren, Hans W.

Kruse, Chris G.

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Article abstract of DOI:10.1021/jm00095a019

The in vitro antiviral and antitumor activities of (-)-debromoeudistomin K (1a) and 10 structural analogues (1b-1j and 11) were evaluated.The synthesis was accomplished with an intramolecular Pictet-Spengler condensation reaction as the key step.This exam

Full text of DOI:10.1021/jm00095a019

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