Asymmetric construction of all-carbon quaternary stereocenters by chiral-auxiliary-mediated claisen rearrangement and total synthesis of (+)-Bakuchiol

Article abstract of DOI:10.3390/molecules171113330

An asymmetric Claisen rearrangement using Oppolzer's camphorsultam was developed. Under thermal conditions, a geraniol-derived substrate underwent the rearrangement with good stereoselectivity. The absolute configuration of the newly formed all-carbon quaternary stereocenter was confirmed by the total synthesis of (+)-bakuchiol from the rearrangement product.

Full text of DOI:10.3390/molecules171113330

Molecules 2012, 17, 13330-13344; doi:10.3390/molecules171113330
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molecules
ISSN 1420-3049
www.mdpi.com/journal/molecules
Article
Asymmetric Construction of All-Carbon Quaternary
Stereocenters by Chiral-Auxiliary-Mediated Claisen
Rearrangement and Total Synthesis of (+)-Bakuchiol
Ken-ichi Takao *, Shu Sakamoto, Marianne Ayaka Touati, Yusuke Kusakawa and
Kin-ichi Tadano *
Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
* Authors to whom correspondence should be addressed; E-Mails: takao@applc.keio.ac.jp
(K.T.); tadano@applc.keio.ac.jp (K.T.); Tel.: +81-45-566-1570 (Ken-ichi Takao);
Fax: +81-45-566-1551 (Ken-ichi Takao).
Received: 9 October 2012; in revised form: 23 October 2012 / Accepted: 2 November 2012 /
Published: 8 November 2012
Abstract: An asymmetric Claisen rearrangement using Oppolzer’s camphorsultam
was developed. Under thermal conditions, a geraniol-derived substrate underwent the
rearrangement with good stereoselectivity. The absolute configuration of the newly formed
all-carbon quaternary stereocenter was confirmed by the total synthesis of (+)-bakuchiol
from the rearrangement product.
Keywords: Claisen rearrangement; chiral auxiliary; camphorsultam; quaternary
stereocenter; total synthesis
1. Introduction
The construction of asymmetric quaternary stereocenters remains a challenge in organic synthesis [1–3].
All-carbon quaternary stereocenters are found in a wide range of complex natural products which share
such a structural motif, including (+)-hyperforin (1) [4], (+)-perforatumone (2) [5,6], (+)-vibsanin A (3) [7],
and (+)-bakuchiol (4) [8–13] (Figure 1). To achieve the total synthesis of these natural products, a
practical method for constructing the quaternary stereocenter is necessary. We focused on the Claisen
rearrangement as an approach to this challenge. The [3,3]-sigmatropic rearrangement of allyl vinyl
ethers, that is, the Claisen rearrangement, is among the most useful tools for forming carbon-carbon
bonds and its asymmetric variants have been well studied [14,15]. Herein, we describe a new method for

Molecules 2012, 17
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the asymmetric construction of an all-carbon quaternary stereocenter by a chiral-auxiliary-mediated
Claisen rearrangement.
Figure 1. Structures of (+)-hyperforin, (+)-perforatumone, (+)-vibsanin A, and (+)-bakuchiol.
2. Results and Discussion
Oppolzer’s camphorsultam was used as a chiral auxiliary for the asymmetric Claisen rearrangement.
We designed a novel substrate, a β-(allyloxy)acrylate derivative bearing the camphorsultam.
Accordingly, N-propioloyl camphorsultam 5 was prepared by our previously reported procedure
(Scheme 1) [16–18]. The oxy-Michael addition of geraniol to 5 in the presence of a catalytic amount of
tributylphosphine gave adduct 6 with complete E-stereoselectivity [19]. A toluene solution of 6 in the
presence of butylated hydroxytoluene (BHT) used as a polymerization inhibitor was heated in a sealed
tube at 140 °C to provide mainly the (2R,3S)-isomer 7a as the rearrangement product in 72% yield,
securing the two contiguous stereocenters including the quaternary carbon. The minor (2S,3R)-isomer
7b (8%) was easily separated from 7a by column chromatography on silica gel [20].
Scheme 1. Claisen rearrangement of geraniol-derived substrate 6.
By using a similar procedure, nerol-derived substrate 8 was prepared from 5 and nerol (Scheme 2).
The Claisen rearrangement of 8 afforded (2R,3R)-isomer 7c and (2S,3S)-isomer 7d, accompanied by a

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small amount of 7a and 7b, respectively. Compared with the case of 6, however, lower
stereoselectivity was observed. Brief exposure of 7a to base caused epimerization at C-2 to produce
isomer 7d, indicating that the quaternary stereocenter in nerol-derived rearrangement product 7c has
stereochemistry opposite to that in 7a.
Scheme 2. Claisen rearrangement of nerol-derived substrate 8.
The stereochemistry of the newly formed quaternary stereocenter (C-3) in 7a was determined by the
total synthesis of (+)-bakuchiol (4), a major component of the Indian medicinal plant Psoralea corylifolia
Linn [8]. Base hydrolysis of 7a followed by decarboxylation provided enantiomerically pure aldehyde
9, and the chiral auxiliary was recovered (Scheme 3). Treatment of 9 with p-MeOC6H4MgBr afforded
alcohol 10, which was subjected to dehydration using phosphoryl chloride to afford bakuchiol methyl
ether 11 [21]. By comparing the optical rotation of synthetic 11 {[α]D25 + 28.4 (c 0.855, CHCl3)} with that
reported for the authentic sample {lit. [α]D29 + 31.2 (c 1.45, CHCl3)} [9], the absolute configuration of
the quaternary stereocenter in 7a was assigned as (S). According to a known procedure [22],
demethylation of 11 finally provided (+)-bakuchiol (4), which was identical to the natural product in
all respects.
Scheme 3. Determination of the stereochemistry at C-3 in 7a and total synthesis of (+)-bakuchiol.

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To determine the configuration at C-2, rearrangement product 7a was heated at 160 °C (Scheme 4).
The intramolecular carbonyl–ene reaction proceeded to provide cyclized 12a as a mixture of four
diastereomers (dr = 3:2:2:1). Similarly, 7c was converted into 12c (dr = 9:8:2:1). Through NOE
experiments on the isolated major diastereomers 12aa and 12ca, the stereochemistry at the C-2 in 7a
and 7c was assigned as (R). Therefore, the configurations of all stereocenters in the rearrangement
products 7a–d were unambiguously assigned.
Scheme 4. Determination of the stereochemistry at C-2 in 7a and 7c.
To expand the scope of this reaction, (E,E)-β-(allyloxy)acrylate substrates 14 and 17 were
synthesized by oxy-Michael addition of allylic alcohols 13 and 16 [23] to 5 (Scheme 5). In both cases,
the Claisen rearrangements of 14 and 17 afforded (2R,3S)-isomers 15a and 18a preferentially, with
good stereoselectivity in more than 70% yield, similarly to the reaction of 6.
Scheme 5. Claisen rearrangements of 14 and 17.

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The vicinal stereocenters in 15a and 18a were assigned by chemical transformation (Scheme 6).
Chemoselective reduction of 7a, followed by acetylation of the resulting alcohol, provided acetate 19a.
13
The spectroscopic data (1H- and C-NMR) of 19a were distinguishable from those of 19b derived
from 7b. On the other hand, 15a was converted into acetate 20a. Desilylation of 20a, oxidation of the
resulting alcohol to aldehyde, and subsequent Wittig olefination afforded 19a whose NMR spectra
matched those of 19a derived from 7a. Compound 18a was also converted into 19a via acetate 21a.
Therefore, the configuration of the vicinal stereocenters at the C-2 and C-3 in 15a and 18a coincides
with that of 7a.
Scheme 6. Determination of the stereochemistry at C-2 and C-3 in 15a and 18a.
The stereochemical outcomes observed in the reactions of 6, 14, 17, and 8 can be explained by the
transition states depicted in Scheme 7.
Scheme 7. Plausible transition states for the Claisen rearrangements of 6, 14, 17, and 8.
O
R
O
O
6, 14, 17
7a, 15a, 18a
N
N

O

SO2
SO2
R
C–Si
C–Re
R
R
O
O
8
7c
O
N
N

O

SO2
SO2
C–Si
C–Re

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In the more favorable conformation of 6, 14, and 17, the carbonyl group is directed anti to the
sulfonyl group and adopts an s-cis conformation with respect to the α,β-unsaturated bond [24]. The
rearrangement proceeds predominantly from the Cα-Re-face through a six-membered chair-like
transition state to avoid the steric repulsion that would be encountered along the Cα-Si-face path. As a
result, 7a, 15a, and 18a were obtained as the major isomers. Also nerol-derived substrate 8 rearranges
through the same Cα-Re-face path to produce 7c. In this case, the bulky homoprenyl group takes an
axial orientation, which causes a decrease of the stereoselectivity.
3. Experimental
General
1
Melting points are uncorrected. Specific rotations were measured in a 100 mm cell. H-NMR
spectra were recorded at 500 MHz with tetramethylsilane as an internal standard on a JEOL JNM-ECA500
spectrometer. 13C-NMR spectra were recorded at 125 MHz. All spectra were recorded in CDCl3.
High-resolution mass spectra (HRMS) were measured in EI mode (70 eV) on a JEOL JMS-GCmate
spectrometer. Thin-layer chromatography (TLC) was performed on Merck Kieselgel 60 F254 plates.
The crude reaction mixtures and extracted materials were purified by column chromatography on
Silica gel 60 (Merck) or Wakogel C-300 (Wako). Unless otherwise noted, reactions were carried out at
room temperature. Combined organic extracts were dried over anhydrous Na2SO4. Solvents were
removed from the reaction mixture and the combined organic extracts by concentration under reduced
pressure using an evaporator with bath at 35–45 °C.
(2R)-N-{(E)-3-[((2E)-3,7-Dimethylocta-2,6-dien-1-yl)oxy]acryloyl}bornane-10,2-sultam (6). The
following reaction was carried out under Ar. To a cooled (0 °C) stirred solution of 5 (302 mg, 1.13 mmol)
in CH2Cl2 (11 mL) were added geraniol (218 μL, 1.24 mmol) and n-Bu3P (42 μL, 0.17 mmol). The
mixture was stirred at 0 °C for 30 min, diluted with H2O (20 mL), and extracted with CH2Cl2 (10 mL × 3).
The combined extracts were washed with saturated brine (20 mL), dried and concentrated under
reduced pressure. The residue was purified by column chromatography on silica gel (EtOAc/hexane,
1:30) to provide 368 mg (77%) of 6 as a colorless oil: TLC Rf 0.54 (EtOAc/hexane, 1:3); [α]D19–59.2
(c 1.19, CHCl3); IR (neat) 2962, 2885, 1678, 1608 cm−1; 1H-NMR (500 MHz): δ 0.97 (s, 3H), 1.18 (s,
3H), 1.34–1.45 (m, 2H), 1.60 (br s, 3H), 1.68 (br s, 3H), 1.71 (br s, 3H), 1.86–1.91 (m, 3H), 2.05–2.17
(m, 6H), 3.43 (d, 1H, J = 13.8 Hz), 3.48 (d, 1H, J = 13.8 Hz), 3.91 (dd, 1H, J = 4.9, 7.7 Hz), 4.45
(d, 2H, J = 6.9 Hz), 5.08 (m, 1H), 5.37 (qt, 1H, J = 1.0, 6.9 Hz), 5.97 (d, 1H, J = 12.1 Hz), 7.70 (d, 1H,
13
J = 12.1 Hz); C-NMR (125 MHz) δ16.6, 17.6, 19.9, 20.7, 25.6, 26.1, 26.5, 32.7, 38.5, 39.4, 44.6,
47.7, 48.2, 53.0, 65.0, 68.1, 97.0, 117.5, 123.5, 131.9, 143.4, 163.3, 164.9; HRMS calcd for
C23H35NO4S (M+) m/z 421.2287, found 421.2286.
(2R)-N-[(2R,3S)-2-Formyl-3,7-dimethyl-3-vinyloct-6-enoyl]bornane-10,2-sultam (7a) and (2R)-N-
[(2S,3R)]-isomer (7b). A solution of 6 (400 mg, 949 μmol) and BHT (10.5 mg, 47.5 μmol) in toluene
(50 mL) was stirred at 140 °C for 65 h in a sealed tube and concentrated under reduced pressure. The
residue was purified by column chromatography on silica gel (EtOAc/hexane, 1:30) to provide 289 mg
(72%) of 7a and 30.9 mg (8%) of 7b. Compound 7a was obtained as white crystals: mp 84–87 °C;

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21
TLC Rf 0.49 (EtOAc/hexane, 1:3); [α]D –77.9 (c 2.55, CHCl3); IR (neat) 2960, 2925, 1730, 1680 cm−1;
1H-NMR (500 MHz) δ 0.98 (s, 3H), 1.15 (s, 3H), 1.26 (s, 3H), 1.37–1.46 (m, 3H), 1.56 (br s, 3H), 1.65
(br s, 3H), 1.67 (m, 1H), 1.87–1.96 (m, 5H), 2.06-2.15 (m, 2H), 3.44 (d, 1H, J = 13.8 Hz), 3.51 (d, 1H,
J = 13.8 Hz), 3.96 (dd, 1H, J = 5.2, 7.4 Hz), 4.01 (d, 1H, J = 2.3 Hz), 5.02 (m, 1H), 5.07 (d, 1H,
J = 17.4 Hz), 5.21 (d, 1H, J = 10.6 Hz), 5.92 (dd, 1H, J = 10.6, 17.4 Hz), 9.61 (d, 1H,
J = 2.3 Hz); 13C-NMR (125 MHz) δ 17.6, 19.7, 19.9, 20.7, 22.2, 25.6, 26.4, 32.9, 38.5 (2C), 44.8, 45.5,
47.7, 48.1, 53.2, 65.4 (2C), 115.2, 123.7, 131.9, 142.3, 167.5, 197.3; HRMS calcd for C23H35NO4S
(M+) m/z 421.2287, found 421.2283. Compound 7b was obtained as white crystals: mp 81–87 °C; TLC
Rf 0.61 (EtOAc/hexane, 1:3); [α]D17+38.5 (c 0.965, CHCl3); IR (neat) 2960, 2925, 1730, 1700 cm−1;
1H-NMR (500 MHz) δ 0.95 (s, 3H), 1.10 (s, 3H), 1.31 (s, 3H), 1.34–1.43 (m, 2H), 1.54-1.68 (m, 2H),
1.56 (br s, 3H), 1.65 (br s, 3H), 1.88-1.93 (m, 5H), 2.08 (dd, 1H, J = 7.8, 13.9 Hz), 2.28 (m, 1H), 3.43
(d, 1H, J = 13.7 Hz), 3.48 (d, 1H, J = 13.7 Hz), 3.90 (dd, 1H, J = 4.9, 7.8 Hz), 4.21 (d, 1H, J = 0.9 Hz),
5.04 (m, 1H), 5.12 (dd, 1H, J = 0.6, 17.5 Hz), 5.26 (dd, 1H, J = 0.6, 10.8 Hz), 6.01 (dd, 1H, J = 10.8,
13
17.5 Hz), 9.60 (d, 1H, J = 0.9 Hz); C-NMR (125 MHz) δ 17.6, 19.3, 19.9, 20.4, 22.2, 25.7, 26.5,
32.7, 38.2, 38.9, 42.9, 44.5, 47.8, 48.2, 53.1, 65.1, 65.3, 115.1, 124.0, 131.7, 143.5, 166.3, 197.7;
HRMS calcd for C23H35NO4S (M+) m/z 421.2287, found 421.2281.
(2R)-N-{(E)-3-[((2Z)-3,7-Dimethylocta-2,6-dien-1-yl)oxy]acryloyl}bornane-10,2-sultam (8). As described
for the preparation of 6, compound 5 (210 mg, 785 μmol) and nerol (155 μL, 882 μmol) were treated
with n-Bu3P (32 μL, 0.12 mmol) in CH2Cl2 (8 mL) to provide 234 mg (71%) of 8 as white crystals: mp
62–64 °C; TLC Rf 0.52 (EtOAc/hexane, 1:3); [α]D26–71.0 (c 1.22, CHCl3); IR (neat) 2964, 2884, 1677,
1607 cm−1; 1H-NMR (500 MHz) δ 0.97 (s, 3H), 1.18 (s, 3H), 1.34–1.45 (m, 2H), 1.60 (br s, 3H), 1.69
(br s, 3H), 1.78 (br s, 3H), 1.87-1.91 (m, 3H), 2.05–2.17 (m, 6H), 3.43 (d, 1H, J = 13.7 Hz), 3.48
(d, 1H, J = 13.7 Hz), 3.91 (dd, 1H, J = 4.9, 7.8 Hz), 4.41 (d, 2H, J = 7.0 Hz), 5.08 (m, 1H), 5.39 (t, 1H,
13
J = 7.0 Hz), 5.96 (d, 1H, J = 12.0 Hz), 7.69 (d, 1H, J = 12.0 Hz); C-NMR (125 MHz) δ 17.6, 19.9,
20.8, 23.5, 25.7, 26.5 (2C), 32.3, 32.8, 38.6, 44.7, 47.8, 48.2, 53.1, 65.0, 67.9, 97.0, 118.5, 123.3,
132.5, 143.8, 163.4, 165.0; HRMS calcd for C23H35NO4S (M+) m/z 421.2287, found 421.2287.
(2R)-N-[(2R,3R)-2-Formyl-3,7-dimethyl-3-vinyloct-6-enoyl]bornane-10,2-sultam (7c) and (2R)-N-
[(2S,3S)]-isomer (7d). As described for the preparation of 7a and 7b from 6, a solution of 8 (223 mg,
529 μmol) and BHT (5.8 mg, 26 μmol) in toluene (27 mL) was heated at 140 °C for 26 h to provide
147 mg (66%) of a mixture of 7c and 7a (7c/7a = 19:1) and 25.0 mg (11%) of a mixture of 7d and 7b
(7d/7b = 10:1), and 27.9 mg (13%) of 8 was recovered. A mixture of 7c and 7a (7c/7a = 19:1) was
obtained as a colorless oil: TLC Rf 0.49 (EtOAc/hexane, 1:3); [α]D28–82.4 (c 1.26, CHCl3); IR (neat)
1
2965, 2930, 1727, 1684 cm−1; H-NMR (500 MHz) for 7c δ 0.97 (s, 3H), 1.16 (s, 3H), 1.26 (s, 3H),
1.34–1.49 (m, 3H), 1.55 (br s, 3H), 1.65 (br s, 3H), 1.68 (m, 1H), 1.84–1.93 (m, 5H), 2.03–2.09 (m,
2H), 3.43 (d, 1H, J = 13.8 Hz), 3.50 (d, 1H, J = 13.8 Hz), 3.89 (d, 1H, J = 3.5 Hz), 3.92 (dd, 1H,
J = 5.5, 7.4 Hz), 5.02 (m, 1H), 5.02 (dd, 1H, J = 1.0, 17.4 Hz), 5.14 (dd, 1H, J = 1.0, 10.9 Hz), 6.02
(dd, 1H, J = 10.9, 17.4 Hz), 9.66 (d, 1H, J = 3.5 Hz); 13C-NMR (125 MHz) for 7c δ 17.6, 18.9, 19.9,
20.7, 22.2, 25.6, 26.4, 33.0, 38.2, 39.5, 44.7, 45.8, 47.7, 48.1, 53.3, 65.4, 65.5, 115.2, 123.7, 131.8,
141.7, 167.9, 197.8; HRMS calcd for C23H35NO4S (M+) m/z 421.2287, found 421.2289. A mixture of
7d and 7b (7d/7b = 10:1) was obtained as a colorless oil: TLC Rf 0.61 (EtOAc/hexane, 1:3); [α]D26+2.9

Molecules 2012, 17
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1
(c 1.25, CHCl3); IR (neat) 2964, 2924, 1728, 1697 cm−1; H-NMR (500 MHz) for 7d δ 0.95 (s, 3H),
1.09 (s, 3H), 1.31–1.42 (m, 2H), 1.34 (s, 3H), 1.57 (m, 1H), 1.57 (br s, 3H), 1.65 (br s, 3H), 1.76 (m,
1H), 1.87–1.95 (m, 5H), 2.07 (dd, 1H, J = 7.9, 14.0 Hz), 2.25 (m, 1H), 3.43 (d, 1H, J = 13.9 Hz), 3.49
(d, 1H, J = 13.9 Hz), 3.90 (dd, 1H, J = 4.9, 7.9 Hz), 4.19 (d, 1H, J = 1.1 Hz), 5.06 (m, 1H), 5.06 (d,
1H, J = 17.2 Hz), 5.17 (d, 1H, J = 10.9 Hz), 6.14 (dd, 1H, J = 10.9, 17.2 Hz), 9.68 (d, 1H, J = 1.1 Hz);
13C-NMR (125 MHz) for 7d δ 17.6, 19.9, 20.4, 21.2, 23.4, 25.6, 26.4, 32.7, 38.2, 39.1, 43.3, 44.5,
47.7, 48.2, 53.1, 65.3, 66.2, 114.7, 123.9, 131.7, 142.6, 166.3, 197.0; HRMS calcd for C23H35NO4S
(M+) m/z 421.2287, found 421.2288.
Epimerization of 7a. To a stirred solution of 7a (7.9 mg, 19 μmol) in CH2Cl2 (1 mL) was added DBU
(3.6 μL, 24 μmol). The mixture was stirred at room temperature for 45 min, diluted with 1 M aqueous
HCl (1 mL), and extracted with CH2Cl2 (2 mL × 3). The combined extracts were washed with
saturated brine (1 mL), dried and concentrated under reduced pressure. The residue was purified by
column chromatography on silica gel (EtOAc/hexane, 1:25) to provide 1.1 mg (14%) of 7d and 6.7 mg
(85%) of 7a was recovered.
(1RS,3R)-1-(4-Methoxyphenyl)-3,7-dimethyl-3-vinyloct-6-enol (10). To a cooled (0 °C) stirred solution of
7a (233 mg, 553 μmol) in THF/H2O (1:1, 5 mL) was added 1.00 M aqueous KOH (1.11 mL, 1.11 mmol).
The mixture was stirred at room temperature for 24 h, quenched with saturated aqueous NH4Cl (2 mL),
diluted with H2O (2 mL), and extracted with Et2O (5 mL × 3). The combined extracts were washed
with saturated brine (15 mL) and dried to provide a solution of aldehyde 9 in Et2O, which was used
in the next step without further evaporation and purification.
The following reaction was carried out under Ar. To a cooled (0 °C) stirred solution of aldehyde 9
in Et2O obtained above was added 4-methoxyphenylmagnesium bromide (1.50 M solution in Et2O,
total 6.27 mL, total 9.41 mmol) in ten times over a period of 2 h. The mixture was quenched with
saturated aqueous NH4Cl (30 mL), diluted H2O (10 mL), and extracted with CH2Cl2 (40 mL × 3). The
combined extracts were dried and concentrated under reduced pressure. The residue was purified by
column chromatography on silica gel (EtOAc/hexane, 1:40) to provide 86.7 mg (55%) of 10 and 114 mg
(96%) of camphorsultam. Compound 10 (dr = 1:1) was obtained as a colorless oil: TLC Rf 0.61
1
(EtOAc/hexane, 1:3); IR (neat) 3442, 2965, 2924, 1612, 1512 cm−1; H-NMR (500 MHz) δ 1.10
(s, 3H × 1/2), 1.11 (s, 3H × 1/2), 1.34 (t, 2H × 1/2, J = 8.5 Hz), 1.40–1.43 (m, 2H × 1/2), 1.57 (br s,
3H × 1/2), 1.59 (br s, 3H × 1/2), 1.66 (br s, 3H × 1/2), 1.67 (br s, 3H × 1/2), 1.80–1.93 (m, 4H), 3.79
(s, 3H), 4.74 (dd, 1H × 1/2, J = 2.6, 8.6 Hz), 4.79 (dd, 1H × 1/2, J = 2.6, 9.3 Hz), 5.02 (dd, 1H × 1/2,
J = 1.1, 17.7 Hz), 5.07 (dd, 1H × 1/2, J = 1.1, 10.8 Hz), 5.07 (m, 1H), 5.07 (dd, 1H × 1/2, J = 0.9,
17.7 Hz), 5.14 (dd, 1H × 1/2, J = 0.9, 10.8 Hz), 5.83 (dd, 1H × 1/2, J = 10.8, 17.7 Hz), 5.97 (dd, 1H × 1/2,
J = 10.8, 17.7 Hz), 6.86 (d, 2H × 1/2, J = 8.8 Hz), 6.86 (d, 2H × 1/2, J = 8.6 Hz), 7.24 (d, 2H × 1/2,
J = 8.8 Hz), 7.25 (d, 2H × 1/2, J = 8.6 Hz); 13C-NMR (125 MHz) δ 17.6, 21.3 (1/2C), 22.5 (1/2C), 22.7
(1/2C), 23.5 (1/2C), 25.7, 39.5, 40.5 (1/2C), 42.5 (1/2C), 50.3 (1/2C), 51.1 (1/2C), 55.3, 71.4 (1/2C),
71.5 (1/2C), 112.2 (1/2C), 112.9 (1/2C), 113.7, 113.8, 124.6 (1/2C), 124.8 (1/2C), 126.9 (2C), 131.2
(1/2C), 131.3 (1/2C), 137.7 (1/2C), 138.3 (1/2C), 147.4 (1/2C), 147.7 (1/2C), 158.8; HRMS calcd for
C19H28O2 (M+) m/z 288.2089, found 288.2090.

Molecules 2012, 17
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(1E,3S)-1-(4-Methoxyphenyl)-3,7-dimethyl-3-vinylocta-1,6-diene (11). The following reaction was
carried out under Ar. To a stirred solution of 10 (22.5 mg, 78.0 μmol) in pyridine (1 mL) was added
POCl3 (8.6 μL, 95 μmol). The mixture was refluxed for 4 h, diluted with EtOAc (15 mL), and washed
with H2O (10 mL) and saturated brine (10 mL). The organic layer was dried and concentrated under
reduced pressure. The residue was purified by column chromatography on silica gel (EtOAc/hexane,
1:100) to provide 18.9 mg (90%) of 11 as a colorless oil: TLC Rf 0.80 (EtOAc/hexane, 1:3);
1
[α]D25+28.4 (c 0.855, CHCl3); IR (neat) 2966, 2916, 1609, 1511 cm−1; H-NMR (500 MHz) δ 1.20 (s,
3H), 1.48–1.51 (m, 2H), 1.58 (br s, 3H), 1.67 (br s, 3H), 1.93–1.98 (m, 2H), 3.80 (s, 3H), 5.01 (dd, 1H,
J = 1.4, 17.5 Hz), 5.03 (dd, 1H, J = 1.4, 10.7 Hz), 5.11 (m, 1H), 5.88 (dd, 1H, J = 10.7, 17.5 Hz), 6.06
(d, 1H, J = 16.4 Hz), 6.26 (d, 1H, J = 16.4 Hz), 6.83 (d, 2H, J = 8.7 Hz), 7.29 (d, 2H, J = 8.7 Hz);
13C-NMR (125 MHz) δ 17.6, 23.2, 23.4, 25.7, 41.3, 42.5, 55.3, 111.8, 113.9 (2C), 124.8, 126.5, 127.1
(2C), 130.7, 131.3, 135.8, 146.0, 158.7; HRMS calcd for C19H26O (M+) m/z 270.1984, found 270.1983.
(+)-Bakuchiol (4). The following reaction was carried out under Ar. To a cooled (0 °C) solution of 11
(30.2 mg, 112 μmol) in Et2O (1 mL) was added MeMgI (0.500 M solution in Et2O, 1.57 mL, 785 μmol).
The solvent was removed under reduced pressure. The residue was heated at 180 °C for 15 min and
cooled to room temperature. The mixture was quenched with 1 M aqueous HCl (2 mL), diluted with
H2O (2 mL), and extracted with CH2Cl2 (5 mL × 3). The combined extracts were dried and
concentrated under reduced pressure. The residue was purified by column chromatography on silica
gel (EtOAc/hexane, 1:60) to provide 26.1 mg (91%) of 4 as a pale yellow oil: TLC Rf 0.63
29
(EtOAc/hexane, 1:3); [α]D + 25.6 (c 0.795, CHCl3); IR (neat) 3359, 2967, 2924, 1610, 1513 cm−1;
1H-NMR (500 MHz) δ 1.19 (s, 3H), 1.47-1.51 (m, 2H), 1.58 (br s, 3H), 1.67 (br s, 3H), 1.93–1.97 (m,
2H), 4.85 (br, 1H, OH), 5.01 (dd, 1H, J = 1.5, 17.4 Hz), 5.03 (dd, 1H, J = 1.5, 10.8 Hz), 5.11 (m, 1H),
5.88 (dd, 1H, J = 10.8, 17.4 Hz), 6.05 (d, 1H, J = 16.2 Hz), 6.25 (d, 1H, J = 16.2 Hz), 6.76 (d, 2H,
J = 8.6 Hz), 7.24 (d, 2H, J = 8.6 Hz); 13C-NMR (125 MHz) δ 17.6, 23.2, 23.3, 25.7, 41.3, 42.5, 111.9,
115.3 (2C), 124.8, 126.4, 127.4 (2C), 130.9, 131.3, 135.9, 145.9, 154.6; HRMS calcd for C18H24O
(M+) m/z 256.1827, found 256.1829.
(2R)-N-[(1R,2S,5R,6R)-6-Hydroxy-5-isopropenyl-2-methyl-2-vinylcyclohexanecarbonyl]bornane-10,2-
sultam (12aa) and its diastereomers. A solution of 7a (22.8 mg, 54.1 μmol) and BHT (a crystal) in
toluene (6 mL) was stirred at 160 °C for 50 h in a sealed tube and concentrated under reduced pressure.
The residue was purified by column chromatography on silica gel (EtOAc/hexane, 1:15) to provide 4.9
mg (21%) of 12aa, 3.2 mg (14%) of 12ab, 3.3 mg (14%) of 12ac, and 1.7 mg (7%) of 12ad.
Compound 12aa was obtained as white crystals: mp 198–200 °C; TLC Rf 0.43 (EtOAc/hexane, 1:2);
1
[α]D21–10.5 (c 0.27, CHCl3); IR (neat) 3520, 2960, 1695 cm−1; H-NMR (500 MHz) δ 0.97 (s, 3H),
1.16 (s, 3H), 1.17 (s, 3H), 1.36–1.44 (m, 2H), 1.51–1.56 (m, 2H), 1.67-1.79 (m, 2H), 1.73 (br s, 3H),
1.86–1.92 (m, 3H), 2.02 (d, 1H, J = 8.3 Hz, OH), 2.08–2.15 (m, 3H), 2.99 (d, 1H, J = 10.6 Hz), 3.47
(d, 1H, J = 13.9 Hz), 3.53 (d, 1H, J = 13.9 Hz), 3.94 (dt, 1H, J = 8.3, 10.6 Hz), 4.00 (dd, 1H, J = 5.1, 7.7
Hz), 4.83 (s, 1H), 4.85 (s, 1H), 4.98 (dd, 1H, J = 1.2, 17.5 Hz), 5.12 (dd, 1H, J = 1.2, 11.2 Hz), 6.43
(dd, 1H, J = 11.2, 17.5 Hz); 13C-NMR (125 MHz) δ 19.2, 20.0, 20.9, 26.4, 26.5, 27.8, 33.0, 38.7, 39.0,
42.5, 44.8, 47.6, 47.7, 53.6, 54.1, 60.7, 65.9, 70.3, 112.5, 113.1, 141.5, 146.2, 171.9; HRMS calcd for
C23H35NO4S (M+) m/z 421.2287, found 421.2291.

Molecules 2012, 17
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(2R)-N-[(1R,2R,5R,6R)-6-Hydroxy-5-isopropenyl-2-methyl-2-vinylcyclohexanecarbonyl]bornane-10,2-
sultam (12ca) and its diastereomers. As described for the preparation of 12aa and its diastereomers
from 7a, a solution of 7c (23.5 mg, 55.7 μmol) and BHT (a crystal) in toluene (6 mL) was heated at
160 °C for 40 h to provide 8.7 mg (37%) of 12ca, 9.2 mg (39%) of a mixture of 12cb and 12cc, and
0.9 mg (4%) of 12cd. Compound 12ca was obtained as white crystals: TLC Rf 0.32 (EtOAc/hexane,
1:2); 1H-NMR (500 MHz) δ 0.95 (s, 3H), 1.15 (s, 3H), 1.19 (s, 3H), 1.23–1.41 (m, 3H), 1.50–1.70 (m,
3H), 1.78 (br s, 3H), 1.81–1.96 (m, 3H), 2.02–2.06 (m, 3H), 2.10 (dt, 1H, J = 5.0, 10.6 Hz), 3.00 (d,
1H, J = 10.5 Hz), 3.45 (d, 1H, J = 13.9 Hz), 3.50 (d, 1H, J = 13.9 Hz), 3.95 (dd, 1H, J = 5.2, 7.8 Hz),
4.00 (q, 1H, J = 10.5 Hz), 4.85 (s, 1H), 4.86 (s, 1H), 4.90 (d, 1H, J = 10.6 Hz), 4.98 (d, 1H, J = 17.5 Hz),
6.00 (dd, 1H, J = 10.6, 17.5 Hz).
(2R)-N-{(E)-3-[((2E)-6-(tert-Butyldiphenysilyloxy)-3-methylhex-2-en-1-yl)oxy]acryloyl}bornane-10,2-
sultam (14). As described for the preparation of 6, compound 5 (109 mg, 408 μmol) and 13 (165 mg,
448 μmol) were treated with n-Bu3P (15 μL, 61 μmol) in CH2Cl2 (4 mL) to provide 223 mg (86%) of
26
14 as white crystals: mp 74–77 °C; TLC Rf 0.78 (EtOAc/toluene, 1:4); [α]D – 45.6 (c 1.02, CHCl3);
IR (neat) 2958, 2858, 1678, 1608 cm−1; 1H-NMR (500 MHz) δ 0.97 (s, 3H), 1.05 (s, 9H), 1.17 (s, 3H),
1.36–1.45 (m, 2H), 1.65–1.70 (m, 2H), 1.67 (s, 3H), 1.86–1.91 (m, 3H), 2.08 (dd, 1H, J = 7.8, 13.8
Hz), 2.13 (t, 2H, J = 7.8 Hz), 2.15 (m, 1H), 3.42 (d, 1H, J = 13.8 Hz), 3.48 (d, 1H, J = 13.8 Hz), 3.64
(t, 2H, J = 6.3 Hz), 3.91 (dd, 1H, J = 4.9, 7.8 Hz), 4.41 (d, 2H, J = 7.1 Hz), 5.35 (t, 1H, J = 7.1 Hz),
13
5.96 (d, 1H, J = 12.0 Hz), 7.36–7.44 (m, 6H), 7.65–7.67 (m, 4H), 7.70 (d, 1H, J = 12.0 Hz); C-NMR
(125 MHz) δ 16.6, 19.2, 19.9, 20.8, 26.5, 26.9 (3C), 30.5, 32.8, 35.7, 38.6, 44.7, 47.8, 48.2, 53.1, 63.3,
65.0, 68.1, 97.0, 117.6, 127.6 (4C), 129.5 (2C), 134.0 (2C), 135.6 (4C), 143.4, 163.4, 165.0; HRMS
calcd for C32H40NO5SSi (M+–t-C4H9) m/z 578.2396, found 578.2398.
(2R)-N-[(2R,3S)-6-(tert-Butyldiphenysilyloxy)-2-formyl-3-methyl-3-vinylhexanoyl]bornane-10,2-sultam
(15a) and (2R)-N-[(2S,3R)]-Isomer (15b). As described for the preparation of 7a and 7b from 6, a
solution of 14 (209 mg, 329 μmol) and BHT (3.6 mg, 16 μmol) in toluene (17 mL) was heated at 140 °C
for 71 h to provide 150 mg (72%) of 15a and 32.1 mg (15%) of 15b. Compound 15a was obtained as a
colorless oil: TLC Rf 0.59 (EtOAc/toluene, 1:5); [α]D23–88.2 (c 1.46, CHCl3); IR (neat) 2961, 2859,
1731, 1686 cm−1; 1H-NMR (500 MHz) δ 0.95 (s, 3H), 1.14 (s, 9H), 1.11 (s, 3H), 1.23 (s, 3H), 1.35–1.40
(m, 2H), 1.48-1.54 (m, 2H), 1.74 (m, 1H), 1.83–1.91 (m, 4H), 2.07–2.13 (m, 2H), 3.43 (d, 1H, J = 13.8
Hz), 3.50 (d, 1H, J = 13.8 Hz), 3.60 (t, 2H, J = 6.3 Hz), 3.95 (dd, 1H, J = 5.4, 7.5 Hz), 4.01 (d, 1H,
J = 2.5 Hz), 5.05 (d, 1H, J = 17.5 Hz), 5.19 (d, 1H, J = 10.9 Hz), 5.88 (dd, 1H, J = 10.9, 17.5 Hz),
13
7.35–7.43 (m, 6H), 7.63–7.65 (m, 4H), 9.60 (d, 1H, J = 2.5 Hz); C-NMR (125 MHz) δ 19.2, 19.8,
19.9, 20.8, 26.4, 26.7, 26.8 (3C), 32.9, 34.5, 38.5, 44.7, 45.3, 47.7, 48.1, 53.2, 63.9, 65.4, 65.5, 115.3,
127.6 (4C), 129.5 (2C), 134.0 (2C), 135.6 (4C), 142.3, 167.4, 197.2; HRMS calcd for C32H40NO5SSi
(M+–t-C4H9) m/z 578.2396, found 578.2401. Compound 15b was obtained as a colorless oil: TLC
Rf 0.69 (EtOAc/toluene, 1:5); [α]D24+6.7 (c 1.50, CHCl3); IR (neat) 2961, 2859, 1728, 1696 cm−1;
1H-NMR (500 MHz) δ 0.94 (s, 3H), 1.04 (s, 9H), 1.10 (s, 3H), 1.27 (s, 3H), 1.33–1.39 (m, 2H), 1.51 (m,
1H), 1.62 (m, 1H), 1.70 (m, 1H), 1.87–1.91 (m, 4H), 2.06 (dd, 1H, J = 7.8, 14.0 Hz), 2.26 (m, 1H),
3.41 (d, 1H, J = 13.7 Hz), 3.48 (d, 1H, J = 13.7 Hz), 3.61 (t, 2H, J = 6.5 Hz), 3.87 (dd, 1H, J = 4.9, 7.8
Hz), 4.20 (s, 1H), 5.09 (d, 1H, J = 17.5 Hz), 5.23 (d, 1H, J = 10.7 Hz), 5.96 (dd, 1H,

Molecules 2012, 17
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J = 10.7, 17.5 Hz), 7.36–7.43 (m, 6H), 7.64–7.66 (m, 4H), 9.59 (s, 1H); 13C-NMR (125 MHz) δ 19.2,
19.5, 19.9, 20.4, 26.4, 26.7, 26.9 (3C), 32.8, 34.9, 38.2, 42.7, 44.5, 47.7, 48.2, 53.1, 64.0, 65.2, 65.3,
115.1, 127.6 (4C), 129.5 (2C), 134.0 (2C), 135.6 (4C), 143.4, 166.3, 197.7; HRMS calcd for
C32H40NO5SSi (M+–t-C4H9) m/z 578.2396, found 578.2389.
(2R)-N-{(E)-3-[((2E)-5-(1,3-Dioxolan-2-yl)-3-methylpent-2-en-1-yl)oxy]acryloyl}bornane-10,2-sultam
(17). As described for the preparation of 6, compound 5 (171 mg, 640 μmol) and 16 (121 mg, 703 μmol)
were treated with n-Bu3P (24 μL, 97 μmol) in CH2Cl2 (6 mL) to provide 222 mg (79%) of 17 as a
colorless oil: TLC Rf 0.67 (EtOAc/toluene, 1:3); [α]D25–59.7 (c 1.16, CHCl3); IR (neat) 2958, 2885,
1
1677, 1609 cm−1; H-NMR (500 MHz) δ 0.97 (s, 3H), 1.18 (s, 3H), 1.34–1.45 (m, 2H), 1.72 (s, 3H),
1.77–1.81 (m, 2H), 1.87–1.91 (m, 3H), 2.07 (dd, 1H, J = 7.8, 13.9 Hz), 2.14 (m, 1H), 2.18 (t, 2H,
J = 8.1 Hz), 3.43 (d, 1H, J = 13.8 Hz), 3.48 (d, 1H, J = 13.8 Hz), 3.84–3.86 (m, 2H), 3.91 (dd, 1H,
J = 5.0, 7.8 Hz), 3.95–3.98 (m, 2H), 4.45 (d, 2H, J = 6.9 Hz), 4.86 (t, 1H, J = 4.7 Hz), 5.41 (t, 1H,
13
J = 6.9 Hz), 5.96 (d, 1H, J = 12.1 Hz), 7.69 (d, 1H, J = 12.1 Hz); C-NMR (125 MHz) δ 16.7, 19.9,
20.8, 26.5, 31.8, 32.7, 33.6, 38.5, 44.6, 47.7, 48.2, 53.0, 64.9 (2C), 65.0, 68.0, 97.0, 104.0, 117.8,
142.7, 163.3, 164.9; HRMS calcd for C22H33NO6S (M+) m/z 439.2029, found 439.2035.
(2R)-N-[(2R,3S)-5-(1,3-Dioxolan-2-yl)-2-formyl-3-methyl-3-vinylpentanoyl]bornane-10,2-sultam (18a)
and (2R)-N-[(2S,3R)]-Isomer (18b). As described for the preparation of 7a and 7b from 6, a solution of
17 (219 mg, 498 μmol) and BHT (5.5 mg, 25 μmol) in toluene (25 mL) was heated at 140 °C for 116 h
to provide 159 mg (73%) of 18a and 34.0 mg (16%) of 18b. Compound 18a was obtained as white
crystals: mp 116–118 °C; TLC Rf 0.67 (EtOAc/toluene, 1:2); [α]D21–119 (c 1.34, CHCl3); IR (neat)
2964, 2886, 1731, 1684 cm−1; 1H-NMR (500 MHz) δ 0.98 (s, 3H), 1.16 (s, 3H), 1.24 (s, 3H), 1.34–1.43 (m,
2H), 1.53–1.63 (m, 2H), 1.81 (m, 1H), 1.88–1.96 (m, 4H), 2.11–2.12 (m, 2H), 3.44 (d, 1H, J = 13.7 Hz),
3.51 (d, 1H, J = 13.7 Hz), 3.80–3.83 (m, 2H), 3.91–3.94 (m, 2H), 3.96 (t, 1H, J = 6.6 Hz), 4.01 (d, 1H,
J = 2.3 Hz), 4.81 (t, 1H, J = 4.2 Hz), 5.08 (d, 1H, J = 17.5 Hz), 5.22 (d, 1H, J = 10.6 Hz), 5.89 (dd, 1H,
J = 10.6, 17.5 Hz), 9.62 (d, 1H, J = 2.3 Hz); 13C-NMR (125 MHz) δ 19.7, 19.9, 20.8, 26.4, 28.0, 32.0,
33.0, 38.5, 44.8, 45.0, 47.7, 48.1, 53.2, 64.9 (2C), 65.4 (2C), 104.3, 115.6, 141.9, 167.4, 197.1; HRMS
calcd for C22H33NO6S (M+) m/z 439.2029, found 439.2036. Compound 18b was obtained as a colorless
oil: TLC Rf 0.75 (EtOAc/toluene, 1:2); [α]D22+10.4 (c 1.67, CHCl3); IR (neat) 2962, 2885, 1728,
1697 cm−1; 1H-NMR (500 MHz) δ 0.94 (s, 3H), 1.10 (s, 3H), 1.29 (s, 3H), 1.32–1.42 (m, 2H), 1.58–1.65
(m, 2H), 1.74 (m, 1H), 1.87–1.94 (m, 4H), 2.07 (dd, 1H, J = 7.8, 13.8 Hz), 2.26 (m, 1H), 3.43 (d, 1H,
J = 13.9 Hz), 3.48 (d, 1H, J = 13.9 Hz), 3.81–3.85 (m, 2H), 3.90–3.95 (m, 3H), 4.21 (s, 1H), 4.82 (t,
1H, J = 4.4 Hz), 5.12 (d, 1H, J = 17.5 Hz), 5.26 (d, 1H, J = 10.9 Hz), 5.98 (dd, 1H, J = 10.9, 17.5 Hz),
13
9.61 (s, 1H); C-NMR (125 MHz) δ 19.2, 19.9, 20.4, 26.4, 28.1, 32.6, 32.7, 38.1, 42.5, 44.5, 47.7,
48.2, 53.0, 64.9 (2C), 65.2 (2C), 104.4, 115.5, 143.0, 166.2, 197.5; HRMS calcd for C22H33NO6S (M+)
m/z 439.2029, found 439.2032.
(2R)-N-[(2R,3S)-2-(Acetoxymethyl)-3,7-dimethyl-3-vinyloct-6-enoyl]bornane-10,2-sultam (19a). To a
cooled (0 °C) stirred solution of 7a (158 mg, 375 μmol) in EtOH (4 mL) was added NaBH4 (14.2 mg,
375 μmol). The mixture was stirred at 0 °C for 4 h, quenched with saturated aqueous NH4Cl (1 mL),
diluted with H2O (20 mL), and extracted with CH2Cl2 (10 mL × 3). The combined extracts were dried

Molecules 2012, 17
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and concentrated under reduced pressure to provide crude alcohol (152 mg), which was used in the
next step without further purification.
To a cooled (0 °C) stirred solution of crude alcohol in CH2Cl2 (4 mL) were added Ac2O (85 μL,
0.90 mmol), Et3N (150 μL, 1.08 mmol), and DMAP (4.4 mg, 36 μmol). The mixture was stirred at
room temperature for 2.5 h, diluted with CH2Cl2 (20 mL), and washed with H2O (10 mL × 2). The
combined aqueous layers were extracted with CH2Cl2 (30 mL). The combined organic layer and
extract were dried and concentrated under reduced pressure. The residue was purified by column
chromatography on silica gel (EtOAc/hexane, 1:15) to provide 137 mg (78% for 2 steps) of 19a as a
colorless oil: TLC Rf 0.61 (EtOAc/hexane, 1:2); [α]D21–38.4 (c 1.46, CHCl3); IR (neat) 2964, 2884,
1
1745, 1690 cm−1; H-NMR (500 MHz) δ 0.96 (s, 3H), 1.10 (s, 3H), 1.13 (s, 3H), 1.27–1.47 (m, 3H),
1.55 (br s, 3H), 1.64 (br s, 3H), 1.65 (m, 1H), 1.81–1.92 (m, 5H), 1.99 (s, 3H), 2.09-2.13 (m, 2H), 3.35
(m, 1H), 3.43 (d, 1H, J = 13.7 Hz), 3.50 (d, 1H, J = 13.7 Hz), 3.94 (t, 1H, J = 6.4 Hz), 4.22 (t, 1H,
J = 10.6 Hz), 4.37 (dd, 1H, J = 3.4, 10.6 Hz), 5.01 (m, 1H), 5.01 (d, 1H, J = 17.5 Hz), 5.16 (d, 1H,
13
J = 10.9 Hz), 5.79 (dd, 1H, J = 10.9, 17.5 Hz); C-NMR (125 MHz) δ 17.5, 17.8, 20.0, 20.4, 20.9,
22.3, 25.6, 26.5, 32.9, 38.6, 38.7, 43.3, 44.5, 47.7 (2C), 52.2, 53.3, 63.0, 65.6, 114.5, 124.1, 131.5,
143.3, 171.0, 172.7; HRMS calcd for C25H39NO5S (M+) m/z 465.2549, found 465.2556.
(2R)-N-[(2S,3R)-2-(Acetoxymethyl)-3,7-dimethyl-3-vinyloct-6-enoyl]bornane-10,2-sultam (19b). As
described for the preparation of 19a from 7a, compound 7b (33.7 mg, 79.9 μmol) was treated with
NaBH4 (1.5 mg, 40 μmol) in EtOH (1 mL) to provide crude alcohol (37.0 mg), which was then treated
with Ac2O (19 μL, 0.20 mmol), Et3N (33 μL, 0.24 mmol), and DMAP (1.1 mg, 9.0 μmol) in CH2Cl2
(1 mL) to provide 24.2 mg (65% for 2 steps) of 19b as a colorless oil: TLC Rf 0.68 (EtOAc/hexane,
1:2); [α]D20–54.7 (c 1.06, CHCl3); IR (neat) 2966, 2886, 1742, 1687 cm−1; 1H-NMR (500 MHz) δ 0.97
(s, 3H), 1.18 (s, 3H), 1.19 (s, 3H), 1.35–1.48 (m, 3H), 1.57 (br s, 3H), 1.61 (m, 1H), 1.65 (br s, 3H),
1.86–1.93 (m, 5H), 1.95 (s, 3H), 2.10 (dd, 1H, J = 7.8, 13.8 Hz), 2.19 (m, 1H), 3.26 (dd, 1H, J = 3.7,
10.6 Hz), 3.47 (d, 1H, J = 13.8 Hz), 3.52 (d, 1H, J = 13.8 Hz), 3.94 (dd, 1H, J = 5.2, 7.8 Hz), 4.06
(t, 1H, J = 10.6 Hz), 4.56 (dd, 1H, J = 3.7, 10.6 Hz), 5.02 (d, 1H, J = 17.4 Hz), 5.06 (m, 1H), 5.16
13
(d, 1H, J = 11.3 Hz), 5.84 (dd, 1H, J = 11.3, 17.4 Hz); C-NMR (125 MHz) δ 17.6, 18.6, 19.9, 20.8,
21.1, 22.5, 25.7, 26.3, 33.0, 37.9, 38.6, 42.4, 44.6, 47.7, 47.8, 52.0, 53.3, 64.6, 65.8, 114.2, 124.5,
131.2, 143.9, 170.6, 172.6; HRMS calcd for C25H39NO5S (M+) m/z 465.2549, found 465.2558.
(2R)-N-[(2R,3S)-2-(Acetoxymethyl)-6-(tert-butyldiphenysilyloxy)-3-methyl-3-vinylhexanoyl]bornane-
10,2-sultam (20a). As described for the preparation of 19a from 7a, compound 15a (150 mg, 236
μmol) was treated with NaBH4 (4.4 mg, 0.12 mmol) in EtOH (3 mL) to provide crude alcohol
(152 mg), which was then treated with Ac2O (56 μL, 0.59 mmol), Et3N (99 μL, 0.71 mmol), and
DMAP (3.0 mg, 25 μmol) in CH2Cl2 (3 mL) to provide 151 mg (94% for 2 steps) of 20a as a colorless
oil: TLC Rf 0.66 (EtOAc/toluene, 1:5); [α]D23–28.6 (c 2.01, CHCl3); IR (neat) 2960, 2859, 1744, 1691
cm−1; 1H-NMR (500 MHz) δ 0.92 (s, 3H), 1.03 (s, 9H), 1.03 (s, 3H), 1.07 (s, 3H), 1.32–1.46 (m, 5H),
1.72 (m, 1H), 1.80 (m, 1H), 1.88–1.90 (m, 2H), 1.98 (s, 3H), 2.06–2.09 (m, 2H), 3.34 (m, 1H), 3.41
(d, 1H, J = 13.8 Hz), 3.47 (d, 1H, J = 13.8 Hz), 3.54–3.60 (m, 2H), 3.92 (t, 1H, J = 6.3 Hz), 4.22 (t, 1H,
J = 10.6 Hz), 4.36 (dd, 1H, J = 3.4, 10.6 Hz), 4.99 (d, 1H, J = 17.5 Hz), 5.13 (d, 1H, J = 11.0 Hz), 5.75
(dd, 1H, J = 11.0, 17.5 Hz), 7.35–7.43 (m, 6H), 7.63-7.64 (m, 4H); 13C-NMR (125 MHz) δ 18.2, 19.1,

Molecules 2012, 17
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19.9, 20.5, 20.9, 26.5, 26.8 (3C), 27.0, 32.9, 34.4, 38.6, 43.0, 44.4, 47.6 (2C), 52.2, 53.3, 63.0, 64.1,
65.6, 114.6, 127.6 (4C), 129.5 (2C), 133.9, 134.0, 135.5 (2C), 135.6 (2C), 143.2, 171.0, 172.6; HRMS
calcd for C34H44NO6SSi (M+–t-C4H9) m/z 622.2659, found 622.2677.
Synthesis of 19a from 20a. To a cooled (0 °C) stirred solution of 20a (12.2 mg, 17.9 μmol) in THF (3 mL)
was added HF·pyridine (0.2 mL). The mixture was stirred at room temperature for 5 h and quenched
with saturated aqueous NaHCO3 (1 mL). This was diluted with H2O (15 mL) and extracted with
CH2Cl2 (10 mL × 4). The combined extracts were dried and concentrated under reduced pressure. The
residue was purified by column chromatography on silica gel (EtOAc/hexane, 1:2) to provide 8.0 mg
20
(quant.) of alcohol as white crystals: mp 113–115 °C; TLC Rf 0.24 (EtOAc/hexane, 1:2); [α]D –42.7
1
(c 1.02, CHCl3); IR (neat) 3529, 2961, 2882, 1741, 1690 cm−1; H-NMR (500 MHz) δ 0.97 (s, 3H),
1.09 (s, 3H), 1.16 (s, 3H), 1.35–1.58 (m, 5H), 1.67 (m, 1H), 1.88-1.92 (m, 3H), 1.99 (s, 3H), 2.09–2.15
(m, 2H), 3.37 (m, 1H), 3.44 (d, 1H, J = 13.9 Hz), 3.50 (d, 1H, J = 13.9 Hz), 3.54 (m, 1H), 3.61 (m,
1H), 3.95 (t, 1H, J = 6.5 Hz), 4.20 (t, 1H, J = 10.7 Hz), 4.40 (dd, 1H, J = 3.4, 10.7 Hz), 5.02 (d, 1H,
J = 17.5 Hz), 5.15 (d, 1H, J = 11.3 Hz), 5.80 (dd, 1H, J = 11.3, 17.5 Hz); 13C-NMR (125 MHz) δ 18.7,
19.9, 20.5, 20.9, 26.5, 27.1, 32.9, 34.4, 38.6, 42.9, 44.5, 47.7 (2C), 51.8, 53.3, 63.0, 63.1, 65.7, 114.5,
143.1, 171.2, 172.6; HRMS calcd for C22H35NO6S (M+) m/z 441.2185, found 441.2192.
To a cooled (0 °C) stirred solution of alcohol (20.9 mg, 47.3 μmol) in CH2Cl2 (1 mL) was added
Dess–Martin periodinane (30.3 mg, 71.4 μmol). The mixture was stirred at room temperature for 2 h
and Dess–Martin periodinane (31.1 mg, 73.3 μmol) was added. After being stirred at room temperature
for 2.5 h, the mixture was quenched with saturated aqueous Na2S2O3 (3 mL) and saturated aqueous
NaHCO3 (3 mL), diluted with H2O (4 mL), and extracted with CH2Cl2 (15 mL × 3). The combined
extracts were washed with saturated brine (20 mL), dried and concentrated under reduced pressure.
The residue was purified by column chromatography on silica gel (EtOAc/hexane, 1:7) to provide 20.8
mg (quant.) of aldehyde as a colorless oil, which was immediately used in the next step: TLC Rf 0.33
1
(EtOAc/hexane, 1:2); H-NMR (300 MHz) δ 0.97 (s, 3H), 1.07 (s, 3H), 1.17 (s, 3H), 1.33–1.48 (m,
4H), 1.68 (m, 1H), 1.89–2.04 (m, 2H), 1.99 (s, 3H), 2.11–2.13 (m, 2H), 2.41 (t, 2H, J = 7.8 Hz), 3.38
(m, 1H), 3.44 (d, 1H, J = 13.9 Hz), 3.52 (d, 1H, J = 13.9 Hz), 3.95 (t, 1H, J = 6.5 Hz), 4.21 (t, 1H,
J = 10.7 Hz), 4.37 (dd, 1H, J = 3.6, 10.7 Hz), 5.05 (d, 1H, J = 17.5 Hz), 5.20 (d, 1H, J = 10.7 Hz), 5.78
(dd, 1H, J = 10.7, 17.5 Hz), 9.73 (s, 1H).
The following reaction was carried out under Ar. To a cooled (0 °C) stirred suspension of
i-PrP+Ph3I− (21.9 mg, 49.1 μmol) in THF (1 mL) was added t-BuLi (1.61 M solution in pentane,
29 μL, 47 μmol). The mixture was stirred at 0 °C for 30 min and a solution of aldehyde (6.9 mg,
16 μmol) in THF (1 mL) was added. After being stirred at 0 °C for 20 min, the mixture was diluted with
H2O (10 mL) and extracted with CH2Cl2 (15 mL × 3). The combined extracts were dried and
concentrated under reduced pressure. The residue was purified by column chromatography on silica
gel (EtOAc/hexane, 1:15) to provide 3.3 mg (45%) of 19a.
(2R)-N-[(2R,3S)-2-(Acetoxymethyl)-5-(1,3-dioxolan-2-yl)-3-methyl-3-vinylpentanoyl]bornane-10,2-sultam
(21a). As described for the preparation of 19a from 7a, compound 18a (154 mg, 350 μmol) was
treated with NaBH4 (6.5 mg, 0.17 mmol) in EtOH (3 mL) to provide crude alcohol (158 mg), which
was then treated with Ac2O (83 μL, 0.88 mmol), Et3N (146 μL, 1.05 mmol), and DMAP (4.4 mg, 36 μmol)

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in CH2Cl2 (4 mL) to provide 150 mg (88% for 2 steps) of 21a as a colorless oil: TLC Rf 0.65
1
(EtOAc/toluene, 1:2); [α]D21–39.5 (c 1.02, CHCl3); IR (neat) 2962, 2884, 1743, 1690 cm−1; H-NMR
(500 MHz) δ 0.97 (s, 3H), 1.08 (s, 3H), 1.16 (s, 3H), 1.36 (m, 1H), 1.43–1.50 (m, 2H), 1.55–1.60 (m,
2H), 1.78 (m, 1H), 1.87–1.91 (m, 3H), 1.99 (s, 3H), 2.11–2.18 (m, 2H), 3.35 (m, 1H), 3.43 (d, 1H,
J = 13.7 Hz), 3.50 (d, 1H, J = 13.7 Hz), 3.78–3.81 (m, 2H), 3.91–3.95 (m, 3H), 4.22 (t, 1H, J = 10.7 Hz),
4.38 (dd, 1H, J = 3.5, 10.7 Hz), 4.76 (t, 1H, J = 4.6 Hz), 5.01 (d, 1H, J = 17.5 Hz), 5.17 (d, 1H,
13
J = 10.7 Hz), 5.77 (dd, 1H, J = 10.7, 17.5 Hz); C-NMR (125 MHz) δ 18.1, 20.0, 20.5, 20.9, 26.5,
28.3, 32.3, 32.9, 38.6, 42.8, 44.5, 47.7 (2C), 52.2, 53.3, 63.0, 64.7, 64.8, 65.6, 104.5, 114.9, 142.9,
171.0, 172.5; HRMS calcd for C24H37NO7S (M+) m/z 483.2291, found 483.2291.
Synthesis of 19a from 21a. A solution of 21a (80.5 mg, 166 μmol) in THF (12 mL) and 4 M aqueous
HCl (12 mL) was stirred at 0 °C for 15 h, diluted with saturated aqueous NaHCO3 (50 mL), and
extracted with CH2Cl2 (60 mL × 3). The combined extracts were dried and concentrated under reduced
pressure. The residue was purified by column chromatography on silica gel (EtOAc/hexane, 1:7) to
provide 58.2 mg (80%) of aldehyde, which was identical with the aldehyde derived from 20a and
converted into 19a as described above.
4. Conclusions
In conclusion, we have developed an asymmetric Claisen rearrangement using Oppolzer’s
camphorsultam as a chiral auxiliary. Notably, rearrangement products 7a, 15a, and 18a possess a
chiral quaternary carbon with high enantiomeric purity. In addition, this method has been applied to
the total synthesis of (+)-bakuchiol (4). Further studies and applications of this work to natural product
synthesis are in progress and will be reported in due course.
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Sample Availability: Not available.
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