Organic & Biomolecular Chemistry
Communication
37 °C (Fig. 2a). The results indicate that 4-methoxybenzene- “the Fundamental Research Funds for the central Universities”
1,2-diamine can selectively react with 5-fdU but not with the (2012203020212).
natural nucleosides. Additionally, we mixed 5-fdU into
aqueous buffer (10 mM CH3COONH4, pH = 4.5) containing the
four natural nucleosides to distinguish the mutated nucleoside Notes and references
5-fdU from natural nucleosides. In Fig. 2b, relative to the
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Acknowledgements
This work was supported by the National Basic Research
Program of China (973 Program) (2012CB720600, 12 Y. Gabe, Y. Urano, K. Kikuchi, H. Kojima and T. Nagano,
2012CB720603), the National Science Foundation of China J. Am. Chem. Soc., 2004, 126, 3357.
(No. 91213302, 21072115), Open funding of the State Key 13 (a) C. S. Uday, D. Koushik, C. Basab, S. K. Mandal,
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Laboratory of Bioorganic and Natural Products Chemistry,
Shanghai Institute of Organic Chemistry, the Chinese
Academy of Sciences; by the Program for Changjiang Scholars
and Innovative Research Team in University (IRT1030); and by
S. Mondal, S. Sen, M. Mukherjee, S. van Smaalen and
P. Chattopadhyay, Org. Lett., 2001, 13, 4510; (b) D. Filippo,
M. Nadai, G. Sattin, L. Pasotti, S. N. Richter and
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