Lipase-catalyzed enantioselective hydrolysis of 4-alkyl-1,4-dihydropyridine derivatives: Synthesis of (+) and (-)-methyl 2-(phenylthio)ethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinecarboxylate (PCA 4248)

Article abstract of DOI:10.1248/cpb.40.1083

Asymmetric synthesis of (+)- and (-)-PCA 4248 (PAF antagonist) was achieved using lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The enzymatic reaction proceeded under the mild conditions in an organic solvent.

Full text of DOI:10.1248/cpb.40.1083

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service