Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog

DOI: 10.1021/jm00045a003

Source and publish data:

Journal of Medicinal Chemistry p. 2991 - 3007 (1994)

Update date:2022-08-04

Topics: Chemical Synthesis In Vivo Studies Pharmacokinetics Bioavailability Efficacy

Authors:

Boyd Boyd

Fung Fung

Baker Baker

Mantei Mantei

Stein Stein

Cohen Cohen

Barlow Barlow

Klinghofer

Wessale Wessale

Verburg Verburg

Polakowski

Adler Adler

Calzadilla

Kovar Kovar

Yao Yao

Hutchins

Denissen

Grabowski

Cepa Cepa

et al. et al.

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Article abstract of DOI:10.1021/jm00045a003

The aim of this study was the discovery of nonpeptide renin inhibitors with much improved oral absorption, bioavailability, and efficacy, for use as antihypertensive agents. Our prior efforts led to the identification of A- 74273 [1, R = 3-(4-morpholino)p

Full text of DOI:10.1021/jm00045a003

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