Journal of Medicinal Chemistry p. 2991 - 3007 (1994)
Update date:2022-08-04
Topics: Chemical Synthesis In Vivo Studies Pharmacokinetics Bioavailability Efficacy
Boyd
Fung
Baker
Mantei
Stein
Cohen
Barlow
Klinghofer
Wessale
Verburg
Polakowski
Adler
Calzadilla
Kovar
Yao
Hutchins
Denissen
Grabowski
Cepa
et al.
The aim of this study was the discovery of nonpeptide renin inhibitors with much improved oral absorption, bioavailability, and efficacy, for use as antihypertensive agents. Our prior efforts led to the identification of A- 74273 [1, R = 3-(4-morpholino)p
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