Synthesis of isomeric 6-trifluoromethyl-3-azabicyclo[31.0]hexanes: Conformationally restricted analogues of 4-trifluoromethylpiperidine

Article abstract of DOI:10.1055/s-0032-1316831

Two isomeric conformationally restricted analogues of 4- trifluoromethylpiperidine were designed. The synthesis was performed in four steps from commercially available N-benzylmaleimide. The key reaction was the [3+2] cycloaddition between trifluoromethyl