Tetrahedron Letters p. 2961 - 2964 (1992)
Update date:2022-07-29
Topics:
Polt, Robin
Li, Yushun
Fernando, Quintus
Rivera, Mario
meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning.DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine.To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using a novel methodology based on the use of sulfenimides derived from cysteine.
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Doi:10.1134/S1070428013030287
()Doi:10.1039/c39920000800
(1992)Doi:10.1016/j.bmc.2013.10.014
(2013)Doi:10.1002/chem.202000252
(2020)Doi:10.1016/S0040-4039(00)92096-3
(1992)Doi:10.1021/ja00126a025
(1995)
