Second-generation auxiliary for the asymmetric addition of metalated tetrahydroisoquinolines to aldehydes

DOI: 10.1016/S0040-4039(00)79567-0

Source and publish data:

Tetrahedron Letters p. 2945 - 2948 (1992)

Update date:2022-07-30

Topics:

Authors:

Zhang, Pingsheng

Gawley, Robert E.

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Article abstract of DOI:10.1016/S0040-4039(00)79567-0

The selectivity of asymmetric addition of tetrahydroisoquinolyloxazoline Grignard reagents to aldehydes has now been improved to 78-82% ds through the use of a camphor-derived auxiliary. The new auxiliary has broad applicability, with overall yields of ch

Full text of DOI:10.1016/S0040-4039(00)79567-0

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Product name:Phenyl-[2-((1R,2S,6R,7S)-1,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-yl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-methanol

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