Synthesis, Chemical Reactivity, and Cytotoxicity of 2-Bis(alkoxycarbonyl)methyliden-1-azabicyclohexane Systems Related to Antitumor Antibiotic Carzinophilin A

DOI: 10.1246/cl.1992.975

Source and publish data:

Chemistry Letters p. 975 - 978 (1992)

Update date:2022-07-30

Topics:

Authors:

Hashimoto, Masaru

Yamada, Kaoru

Terashima, Shiro

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Article abstract of DOI:10.1246/cl.1992.975

Enantiomeric pairs of the title compounds were synthesized starting from (S)- and (R)-pyroglutamic acid.They were found to be susceptible to nucleophilic ring opening of aziridine moieties and to exhibit weak in vitro cytotoxicity.

Full text of DOI:10.1246/cl.1992.975

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