Synthesis, Chemical Reactivity, and Cytotoxicity of 2-Bis(alkoxycarbonyl)methyliden-1-azabicyclohexane Systems Related to Antitumor Antibiotic Carzinophilin A

Article abstract of DOI:10.1246/cl.1992.975

Enantiomeric pairs of the title compounds were synthesized starting from (S)- and (R)-pyroglutamic acid.They were found to be susceptible to nucleophilic ring opening of aziridine moieties and to exhibit weak in vitro cytotoxicity.