Molecules p. 140 - 153 (2013)
Update date:2022-08-03
Topics:
Kang, Jae Eun
Cho, Jung Keun
Curtis-Long, Marcus J.
Ryu, Hyung Won
Kim, Jin Hyo
Kim, Hye Jin
Yuk, Heung Joo
Kim, Dae Wook
Park, Ki Hun
The action of β-secretase (BACE1) is strongly correlated with the onset of Alzheimer's disease (AD). Aminochalcone derivatives were examined for their ability to inhibit BACE1. Parent aminochalcones showed two digit micromolar IC50s against BACE1. Potency
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Doi:10.1016/j.jorganchem.2013.02.003
(2013)Doi:10.1002/anie.201209706
(2013)Doi:10.1016/j.tet.2013.03.103
(2013)Doi:10.1039/c3dt32710h
(2013)Doi:10.1007/s11172-012-0161-z
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