Synthetic Communications p. 1895 - 1911 (1992)
Update date:2022-07-30
Topics:
Langlois
Meyer
Soulier
The synthesis of (R) and (S)-3-amino quinuclidine, an important building block for the synthesis of chiral 5-HT3 serotonin receptor antagonists, is described. The key reaction is the reduction by NaBH4 of the imine prepared from the 3-quinuclidinone and chiral (S) or (R)-1-phenethylamine.
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