Synthesis of (R) and (S)-3-aminoquinuclidine from 3-quinuclidinone and (S) and (R)-1-phenethylamine

Article abstract of DOI:10.1080/00397919208021320

The synthesis of (R) and (S)-3-amino quinuclidine, an important building block for the synthesis of chiral 5-HT₃ serotonin receptor antagonists, is described. The key reaction is the reduction by NaBH₄ of the imine prepared from the 3-quinuclidinone and chiral (S) or (R)-1-phenethylamine.

Full text of DOI:10.1080/00397919208021320

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Synthetic Communications: An
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Synthesis of (R) and (S)-3-
Aminoquinuclidine from 3-
Quinuclidinone and (S) and
(R)-1-Phenethylamine
Michel Langlois a , Christine Meyer a & Jean Louis
Soulier a
a CNRS-CERCOA, 2-8 rue Henri, Dunant, F-94320,
THIAIS
Available online: 23 Sep 2006
To cite this article: Michel Langlois, Christine Meyer & Jean Louis Soulier (1992):
Synthesis of (R) and (S)-3-Aminoquinuclidine from 3-Quinuclidinone and (S) and (R)-1-
Phenethylamine, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 22:13, 1895-1911
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