Journal of Medicinal Chemistry p. 3492 - 3506 (2013)
Update date:2022-08-02
Topics:
Patil, Vishal
Sodji, Quaovi H.
Kornacki, James R.
Mrksich, Milan
Oyelere, Adegboyega K.
Small molecules bearing hydroxamic acid as the zinc binding group (ZBG) have been the most effective histone deacetylase inhibitors (HDACi) to date. However, concerns about the pharmacokinetic liabilities of the hydroxamic acid moiety have stimulated rese
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