Condensed heteroaromatic ring systems. XX. Palladium-catalyzed carbonylative coupling of iodobenzenes with (Z)-1-ethoxy-2-(tributylstannyl)ethene

Article abstract of DOI:10.1248/cpb.40.1137

Palladium-catalyzed cross-coupling reaction of iodobenzene and its 4-substituted derivatives, except for 4-nitroiodobenzene, with (Z)-1-ethoxy-2-(tributylstannyl)ethene under a carbon monoxide atmosphere (5 atm) gave the corresponding (E)-3-ethoxy-1-arylprop-2-en-1-ones in considerable yields. Syntheses of chromone and 4(1H)-quinolinone were accomplished by application of this method to 2-(methoxymethoxy)iodobenzene and ethyl 2-iodophenylcarbanylate, respectively. The results obtained on the carbonylative coupling reaction of halopyridines are also described.

Full text of DOI:10.1248/cpb.40.1137

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