Tetrahedron Letters p. 1019 - 1022 (1994)
Update date:2022-08-04
Topics:
Adamczyk, Maciej
Gebler, John C.
Mattingly, Phillip G.
Benzyl and methyl esters of rapamycin 42-hemisuccinate were hydrolyzed under very mild conditions to the rapamycin hemisuccinate using lipase from Pseudomonas sp. This selective deprotection was performed on a ≥100 mg scale for both esters resulting in 50% isolated yield from the methyl ester and 29% from the benzyl ester of the desired acid.
View MoreShenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)
Contact:+86-21-54159691
Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Yixing Bluwat Chemicals Co., Ltd.
Contact:+86 510 87821568
Address:Yongan Road, Yixing Chemical Industrial Park, Yixing, Jiangsu, China
Contact:+86-511-88790000
Address:338 North Yushan Rd, Zhenjiang, Jiangsu 212016
HANGZHOU FOREWIN PHARMA CO., LTD
Contact:+86-571-89053961
Address:hangzhou
Contact:+86-10-59484199
Address:No.58-A1026 Liangguan Street
Doi:10.3109/14756366.2012.755623
(2014)Doi:10.1134/S1070427213110062
(2013)Doi:10.3184/174751913X13843392957323
(2013)Doi:10.1016/S0040-4020(01)90412-0
(1994)Doi:10.1016/0223-5234(94)90041-8
(1994)Doi:10.1021/ol403598k
(2014)
