Lipase mediated hydrolysis of rapamycin 42-hemisuccinate benzyl and methyl esters

Article abstract of DOI:10.1016/S0040-4039(00)79954-0

Benzyl and methyl esters of rapamycin 42-hemisuccinate were hydrolyzed under very mild conditions to the rapamycin hemisuccinate using lipase from Pseudomonas sp. This selective deprotection was performed on a ≥100 mg scale for both esters resulting in 50% isolated yield from the methyl ester and 29% from the benzyl ester of the desired acid.