Tetrahedron Letters p. 1019 - 1022 (1994)
Update date:2022-08-04
Topics:
Adamczyk, Maciej
Gebler, John C.
Mattingly, Phillip G.
Benzyl and methyl esters of rapamycin 42-hemisuccinate were hydrolyzed under very mild conditions to the rapamycin hemisuccinate using lipase from Pseudomonas sp. This selective deprotection was performed on a ≥100 mg scale for both esters resulting in 50% isolated yield from the methyl ester and 29% from the benzyl ester of the desired acid.
View MoreChangzhou naidechemical Co.Ltd
Contact:+86-519-82589807
Address:NO.25,Houyang street,Jintan,Changzhou City
Huaian Double Win Chemicals Co.,Ltd.
Contact:+86-13511538872
Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China
website:http://www.herbpurify.com
Contact:0086-028-85249238
Address:Room709-C1,Incubator Building, Tianfu Life Science Park No.88,Keyuan Road,Gaoxin district,Chengdu City,Sichuan Prov,China
Contact:+86-25-85281586
Address:13F,Bld2#,South of Longpan Road
Contact:+852 83038667
Address:Room 1502, 15th Floor, SPA Centre,53-55 Lockhart Road, Wanchai, Hong Kong
Doi:10.3109/14756366.2012.755623
(2014)Doi:10.1134/S1070427213110062
(2013)Doi:10.3184/174751913X13843392957323
(2013)Doi:10.1016/S0040-4020(01)90412-0
(1994)Doi:10.1016/0223-5234(94)90041-8
(1994)Doi:10.1021/ol403598k
(2014)
