Tetrahedron Letters p. 1019 - 1022 (1994)
Update date:2022-08-04
Topics:
Adamczyk, Maciej
Gebler, John C.
Mattingly, Phillip G.
Benzyl and methyl esters of rapamycin 42-hemisuccinate were hydrolyzed under very mild conditions to the rapamycin hemisuccinate using lipase from Pseudomonas sp. This selective deprotection was performed on a ≥100 mg scale for both esters resulting in 50% isolated yield from the methyl ester and 29% from the benzyl ester of the desired acid.
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