On a Practical Synthesis of β-Hydroxy Fatty Acid Derivatives

Article abstract of DOI:10.1016/0957-4166(95)00106-Y

An efficient synthesis of three homochiral β-hydroxy fatty acid derivatives, which have been utilized in our total synthesis of lipid A, is reported.The synthesis features Sharpless asymmetric dihydroxylation of an unsaturated ester, regioselective conversion of a diol into acyloxy chlorides, and a reductive removal of the chloro group.