Bioorganic and Medicinal Chemistry Letters p. 2688 - 2691 (2013)
Update date:2022-08-05
Topics:
Shook, Brian C.
Chakravarty, Devraj
Barbay, J. Kent
Wang, Aihua
Leonard, Kristi
Alford, Vernon
Powell, Mark T.
Rassnick, Stefanie
Scannevin, Robert H.
Carroll, Karen
Wallace, Nathaniel
Crooke, Jeffrey
Ault, Mark
Lampron, Lisa
Westover, Lori
Rhodes, Kenneth
Jackson, Paul F.
A novel series of benzyl substituted thieno[2,3-d]pyrimidines were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse catalepsy in mice when dosed orally.
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Doi:10.1002/anie.201208991
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(2013)