Novel 3,3-disubstituted oxindole derivatives. Synthesis and evaluation of the anti-proliferative activity

DOI: 10.1016/j.bmcl.2019.126845

Source and publish data:

Bioorganic and Medicinal Chemistry Letters (2020)

Update date:2022-07-31

Topics:

Authors:

Christodoulou, Michael S.

Nicoletti, Ferdinando

Mangano, Katia

Chiacchio, Maria Assunta

Facchetti, Giorgio

Rimoldi, Isabella

Beccalli, Egle M.

Giofrè, Sabrina

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Article abstract of DOI:10.1016/j.bmcl.2019.126845

3,3-Disubstituted oxindole derivatives bearing a nitrogen atom at the C-3 position have been synthesized starting from 3-alkyl oxindole through a metal free pathway. These derivatives have been tested in five human tumor cell lines (PC3, MCF7, SW620, MiaP

Full text of DOI:10.1016/j.bmcl.2019.126845

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