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Cobalt doped ZnS NPs catalyzed novel strategy has been devel-
oped to generate a diverse array of pyrazolones (with excellent
regioselectivity) and 1,3-oxathiolan-5-one derivatives, each rep-
resenting a privileged medicinal scaffold using infrared irradiation
as the heating mode. The proposed synthetic protocol allowed a
straightforward preparation of an array of molecules spanning a
broad range of molecular diversity. About 40-fold higher catalytic
activity was observed for nanocatalyst under IR than that under
conventional method. The results suggested that IR and nanocat-
alyst had a synergistic effect. Catalytic processes with shorter
reaction times safeguard the catalyst from deactivation and decom-
position. The positive effect of cobalt doping in catalyst ZnS NPs on
reaction rate acceleration was attributed to an increase in surface
acidity. Elimination of corrosive liquid acids, conventional organic
solvents, and toxic reagents, recycling and economic viability of
the catalyst, atom-economy, low catalyst loading, broad substrate
applicability and formation of water as the only by-product are
additional advantages of the present methodology relevant to
green chemistry. Further exploration of the cobalt doped ZnS NPs
and biological evaluation of the synthesized libraries are in progress
and will be reported in due course.
Acknowledgements
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Financial assistance from the CSIR New Delhi is gratefully
acknowledged. We are also thankful to the Central Drug Research
Institute (CDRI), Lucknow, for the spectral analyses.
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