Journal of Pharmaceutical Sciences p. 397 - 398 (1992)
Update date:2022-09-26
Topics:
Jones Jr.
Bylund
Hanson
The p-aminobenzyl analogues (8a and 8b, respectively) of the cardioselective β-adrenergic receptor antagonists practolol and atenolol were prepared from the corresponding phenoxymethyloxiranes in 30 and 13% yields, respectively. The dissociation constants for the β-adrenergic receptor were measured in membrane preparations of rat heart and lung. In membranes from the heart (which contain mostly β1-adrenergic receptors), the affinities of the derivatives and parent compounds were similar. By contrast, in membranes from the lung (which contain mostly β2-adrenergic receptors), the derivatives were more potent than the parent compounds. Thus, the cardioselectivities of the p-aminobenzyl analogues 8a and 8b were about one-sixth those of the respective parents.
View MoreShenzhen JYMed Technology Co.,Ltd.
website:http://www.jymedtech.com
Contact:+86-755-26612112
Address:1#8,9/F, Biomedicine innovation Industrial Park, No.14, Jinhui Road, Pingshan Sistrict, Shenzhen, China
Xi'an caijing Opto-Electrical Science & Technology Co., LTD
Contact:+86-29-88294447
Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
Shantou Baokang Pharmaceutical Co., Ltd.
Contact:+86-754-88873487
Address:5/F B Block Huangshan Bldg Huangshan Rd Shantou
Shanghai Synmedia Chemical Co., Ltd
Contact:+86-21-38681880
Address:6th Floor, 11A Building, No.528 Ruiqing Road, Heqing town, Pudong new district, Shanghai China
Contact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
Doi:10.1021/ml4001112
(2013)Doi:10.1016/j.ejmech.2018.03.051
(2018)Doi:10.1039/c3dt32843k
(2013)Doi:10.1039/c9sc06511c
(2020)Doi:10.1021/ml4000707
(2013)Doi:10.1002/ejoc.201701814
(2018)