Simplified method for the isolation of thermally labile drug-DNA adducts: Characterization of chlorambucil and carzinophilin/azinomycin B alkylation products

DOI: 10.1016/0040-4039(92)80005-5

Source and publish data:

Tetrahedron Letters p. 3711 - 3714 (1992)

Update date:2022-08-04

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Authors:

Salvati, Mark E.

Moran, Edmund J.

Armstrong, Robert W.

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Article abstract of DOI:10.1016/0040-4039(92)80005-5

A simple and rapid method has been developed for the isolation of thermally labile DNA alkylation products. Use of calf thymus DNA in combination with size exclusion filtration provides good yields >40% of chlorambucil-guanine adducts. Application of this

Full text of DOI:10.1016/0040-4039(92)80005-5

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