Azide- Or fluorine-containing 2′ & 3′-azolyluridines by regioselective opening of 1-(2′,3′-anhydro-β-d-lyxofuranosyl)uracils

Article abstract of DOI:10.1016/0040-4039(92)88102-B

Azide- or fluorine-containing imidazol-1-yl, pyrazol-1-yl, and 1,2,4-triazol-1-yl 2′,3′-dideoxyuridines have been synthesized from uridine in 5-6 steps, via <2′,3′-β-cpoxy ? derivatives. Regioselective oxirane-ring openings have been accomplished by appropriate choice of the reactions conditions.