Synthesis and heteronuclear NMR analysis of deuterium- and tritium-labelled methylenebisphosphonic acid

Article abstract of DOI:10.1016/S0040-4039(00)74821-0

Deuterium has been substituted into the methylene group of methylenebisphosphonic acid, MDP. Analysis of the phosphorus NMR spectrum of the product shows a linear high-frequency shift on sequential mono- and di-deuteriation. The corresponding tritium labelling of MDP achieved a specific activity of 30 mCi/mmol.